Onco Actu du 19 janvier 2016

	1. Biologie
Decoding cancer’s secret diary [Cancer Research UK] In other words, the genetic alterations of cells within the cancer are like a ‘secret diary’, written as the cancer developed. And the mathematical formula we found is akin to a grammatical rule for decoding the words within it. By reading the diary with the help of this rule, we could see exactly how the cancer had grown.
Laws of nature predict cancer evolution [The Institute of Cancer Research] The model, created by the research team, predicted that in many tumours, all important cancer genes are already present at the beginning of tumour growth, and new mutations inside the tumour are essentially ‘passengers’, with no additional effect.
In defence of model organisms [Ewan's Blog: Bioinformatician at large] There are no easy answers to these questions, but we do need to realise that the lines between ‘basic’ and ‘translational’ research are now fully blurred – both are essential parts of the same process of understanding life, with massive spill-over effects across many practical aspects of our world, our health above all.
	3. Prévention
New Dietary Guidelines spark intense debate among nutrition experts [LA Times] After the release of the scientific advisory report, which urged language limiting red meat consumption, "there was a lot of pushback or interference by the food industry, Congress and special interest groups," Hu said. "That has certainly influenced the translation of the scientific evidence into the policy document."
	3.1 Tabac
Are ads for candy-flavoured e-cigs tempting teens to vape? [NHS Choices] The findings definitely seem suggestive, but other things besides adverts could influence a child's actions, including socioeconomic factors, personal characteristics, lifestyle, and peer pressure.
	4. Dépistage, diagnostic et pronostic
The Bigger Picture - Does imaging have a role in cancer evolution? [The Institute of Cancer Research] The imaging techniques currently of greatest value in providing a range of information that can be fused are MRI and PET. Newer hardware combining these modalities into a single scanner has recently become available and will hugely advance the investigation of tumour biology.
	4.9 Dép., diag. & prono. - Sein
Essay: Insurer Rewards Push Women Toward Mammograms [NY Times] In short: Don’t pay women to get mammograms — pay them to use a tool to decide whether they should get mammograms.
	5.12 Immunothérapies
Cancer drugs could be re-purposed to fight Alzheimer's disease [The Telegraph] "There is currently no cure or disease-modifying treatment for Alzheimer’s disease, and the prospect of using PD-1 blockers, may suggest short translation to the clinic."
	5.3 Traitements - FDA, EMA,...
FDA criticised for safety data flaws [Pharmafile] The US Government Accountability Office (GAO), an independent organisation that scrutinises Government agencies and how they perform the constitutional duties, says the Agency is failing in its responsibility to monitor the safety of drugs approved through its expedited programs.
	5.4 Traitements - Economie
Oncobiologics looks to a $115M IPO to back its biosimilars business [FierceBiotech] Oncobiologics CEO Pankaj Mohan is turning to a turbulent public market to provide the next big injection of cash that will be needed to keep his knockoffs of Humira and Avastin on their Phase III development schedules.
	6. Lutte contre les cancers
David Bowie thanked by Cardiff end-of-life care doctor [BBC News] "In fact, your story became a way for us to communicate very openly about death, something many doctors and nurses struggle to introduce as a topic of conversation."
	6.1 Observation
32,500 British women unknowingly carry deadly ovarian cancer gene [The Telegraph] Around 1.8 women in every 100 develops the disease. But this risk increases to around 5.8 women in every 100 who have the mutated BRIP1 gene. It’s estimated that one in every 1,000 UK women have the gene fault.
	6.10 Politiques
Obama's bet on science about far more than 'moonshot' [STAT] To anyone who follows science, President Barack Obama’s announcement of a “moonshot” to cure cancer last week brought on a strong sense of déjà vu. It was, in fact, the third time in less than three years that he has launched a high-profile effort to solve a complex biomedical problem.
	6.7 DMP, Big Data & applis
Cancer cures should focus on prevention, best practices [Modern Healthcare] Care for patients with cancer is a vast, unobserved and uncontrolled science experiment where the outcomes are never gathered, the data are never analyzed and the findings are never disseminated. Until the research paradigm changes, we will make only marginal progress against the disease.