Onco Actu du 14 janvier 2016

	1. Biologie
Fat may fuel prostate cancer growth [BBC News] The French investigators found that fat cells release a protein that drives prostate cancer's spread in mice. Human fat cells release the same protein, they told Nature Communications.
	3.3 Prévention - Vaccins
HPV Vaccine Uptake is Highest Among Girls in High Poverty and Majority Hispanic Communities [AACR] “Our findings that the rates of HPV vaccine initiation are highest among adolescent girls living in high-poverty communities and majority Hispanic communities, which generally have higher than average poverty rates, are contrary to conventional beliefs that socioeconomic disadvantage is a barrier to health care.”
HPV Vaccine Safety and Acceptance [Science-Based Medicine] I have noticed a common strategy among ideologues who oppose a safe and effective new technology or who deny an accepted science – they use lies and distortion to generate public resistance to the thing they oppose, and then cite the resistance they helped to generate as evidence that there must be a real problem.
HPV vaccine uptake highest in Hispanic, low-income communities [Fred Hutch] Researchers found that HPV vaccine uptake is highest in high poverty and predominantly Hispanic communities. In fact, Hispanic families living in predominantly non-Hispanic white communities were no more likely than their white neighbors to choose the vaccine.
	4.12 Biopsies liquides
Grail’s search for a universal cancer screen: noble quest or fool’s errand? [HealthNewsReview] We need to conduct randomized trials comparing disease-specific mortality between screened and unscreened populations. Unfortunately for screening enthusiasts and investors, these studies require enrolling tens of thousands of patients and following them for at least a decade in order to know whether screening is efficacious—and to be able to appreciate the potential harms of screening.
	5.12 Immunothérapies
Pfizer says its CAR T cancer therapy could outshine rivals [Pfizer] With its French partner Cellectis, Pfizer is in the early stages of developing new cancer treatments called CAR T cells it says has major medical and manufacturing advantages over similar cell therapies being developed by others.
	5.2.1 Pharma - Partenariats
Kite Pharma and Leiden University Medical Center Sign Research and License Agreement for T Cell Receptors Targeting HPV-Associated Cancers [Kite Pharma] Kite Pharma EU, based in Amsterdam, is focused on the discovery and development of tumor-specific TCRs for broad use in cancer treatment based on its TCR-GENErator™ platform.
	5.5 ASCO
2016 Quality Care Symposium Press Program to Highlight Practical and Data-Driven Strategies to Improve Cancer Care; Housing Deadline is January 20 [ASCO] This year’s Symposium will take place February 26–27, 2016, at the JW Marriott Phoenix Desert Ridge in Phoenix and feature more than 300 abstracts on the latest research related to quality of cancer care.
	6. Lutte contre les cancers
The route to ‘precision’ medicine – four key challenges we need to meet [Cancer Research UK] Science has delivered an understanding of cancer that was almost unimaginable just a decade ago. But bringing these advances to patients routinely is proving challenging. We can see the size and shape of the prize but it remains, for many, tantalisingly out of reach.
	6.10 Politiques
The President’s Cancer Moonshot: An Opportunity to Save Lives [ACS] “Cancer will not be cured this year. But we should do all we can to ensure 2016 is remembered as the year we came together in an effort to work smartly, and with all the resources we needed, to harness the power in our hands to reduce the devastating impact of cancer.”
Biden maps out a 'moonshot' approach to cancer with plans to 'break down silos' in R&D [FierceBiotech] The specifics remain unclear, but Biden has hinted at a widespread data-sharing program between industry and academia, and he has promised to unite oncology experts with cabinet secretaries to figure out how the U.S. can help remove barriers to R&D advancement.
Obama's Anti-Cancer Moonshot Will Need More Than Research [WIRED] More Americans die of heart disease each year than anything else, but cancer has better lobbyists. And now it’s getting an especially powerful one: Vice President Joe Biden.
What Vice President Biden’s moonshot may mean for cancer research [Science] One thing AACR hopes won’t happen is that Biden will move money around in the 2016 budget already underway. “We don’t want to see reallocation of existing dollars at NIH to pay for this initiative,” Retzlaff says.
‘Moonshot’ to Cure Cancer, to Be Led by Biden, Relies on Outmoded View of Disease [NY Times] Unlike in 1971, when President Nixon launched his cancer war, researchers now understand that cancer is not one disease but essentially hundreds. The very notion of a single cure — or as Mr. Obama put it, making “America the country that cures cancer once and for all” — is misleading and outdated.
A 'moonshot' to cure cancer: Realistic hope or a search for green cheese? [LA Times] Calling for a cure "is not overselling," said Dr. Neel, who directs Langone's Laura and Isaac Perlmutter Cancer Center. A slow, steady wearing down of the opposition is no less a victory over cancer, he said. But it can only come when infusions of federal research dollars are available to carry new findings forward.
Experts offer advice on Joe Biden's cancer 'moonshot' project [STAT] STAT asked experts inside and outside the cancer world what advice they would offer the vice president to help move his project forward: Barrett Rollins: Share data from cancer patients Otis Brawley: Use influence even after leaving office Austin Frakt: Invest in data infrastructure and access
	6.11 Patients
How A Little Boy's Cancer Diagnosis Inspired A Haunting Video Game [NPR] When Ryan Green's son Joel was 1 year old he was diagnosed with an aggressive brain cancer. Over the next few years, he underwent rounds of chemotherapy and radiation, only to have the cancer return. Feeling helpless, Ryan turned to what he knew as a video game developer.