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3.1 Tabac
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If
you were to go on the media reports alone, you’d be forgiven for being
alarmed. But as is so often the case in the reporting of science and
risk, taking a deeper look behind the headlines reveals a very different
story.
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4.12 Biopsies liquides
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Detection
of the NPM1 gene in patients’ blood after chemotherapy indicated a
greater risk of their disease returning: 82 per cent of patients with
traces of NPM1 in a blood sample had relapsed within three years. In
contrast, just 30 per cent of patients who had no detectable NPM1 in
their blood cells went on to relapse within that time.
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4.2 Dép., diag. & prono. - Génome
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The
sisters are taking part in the 100,000 Genomes Project, run within the
NHS, which is trying to understand the mutations that cause or increase
the risk of cancer. It will also determine the drugs that can target
tumours.
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4.5 Dép., diag. & prono. - Colorectal
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The
investigators describe a novel approach used to identify a tumor marker
called CDX2 that might predict prognosis and determine which patients
with stage-II colon cancer might benefit from adjuvant chemotherapy,
rather than surgery alone.
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5. Traitements
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Novel drug-delivery system cuts off common treatment escape pathways in animal models.
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5.10 Traitements - Essais
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I
looked up two random studies on roche-trials.com. Both are oncology
trials of unapproved, investigational drugs. Neither roche-trials.com
webpage includes a link to the protocol. I wrote Roche, but they
suggested I was looking in the wrong place and directed me to the US
ClinicalTrials.gov and the EMA EUdraCT.
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Dr.
Darren B. Taichman, lead author of the editorial and deputy editor of
the Annals of Internal Medicine, said the proposal assumes data from
each study would be made available according to a sharing plan written
by the trial researchers.
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5.2 Pharma
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Venetoclax
is an inhibitor of the B-cell lymphoma-2 (BCL-2) protein being
developed by AbbVie in partnership with Genentech and Roche.
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5.2.1 Pharma - Partenariats
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Under
the terms of the agreement which was entered into in May of 2014,
CytomX granted Bristol-Myers Squibb exclusive worldwide rights to
develop and commercialize Probodies for up to four oncology targets
including CTLA-4, a clinically validated immune inhibitory checkpoint
receptor.
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5.4 Traitements - Economie
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Debates
about whether and how to reduce drug prices aren’t new. But they rarely
lead to legislative success. Still, the mere threat of government price
controls may have a moderating effect on drug prices.
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6. Lutte contre les cancers
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Through
a combination of next-generation technology, and expertise ranging from
physics and maths to biology and computing, we want to build the
ultimate map of cancer.
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Researchers
analyzed survey responses from 126 women undergoing mastectomies and
found most of them reported discussing reconstruction with their
doctors, but only 58 percent recalled specific conversations about the
benefits of this option and just 28 percent remembered talking about the
risks.
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6.1 Observation
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Among
women under 50 with malignant melanoma, those diagnosed during or soon
after pregnancy were significantly more likely to have tumors spread to
other organs and tissues, and were also much more likely to have the
cancer recur after treatment, the study found.
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6.10 Politiques
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In
some ways, Biden--tasked with overseeing the president's cancer
"moonshots" program--is several years late to the kickoff of a new era
in cancer drug R&D.
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Whether
cures for cancer are realized through personalized medicine, cancer
vaccines, immunotherapy, or a combination of these or other
developments, the panelists in Davos confirmed that the technology that
allows researchers to collaborate will play a leading role.
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6.6 Publications
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The notices follow four retractions — two for image duplications and two for unknown reasons — for Anil K. Jaiswal.
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