Onco Actu du 2 décembre 2015

	1. Biologie
Cancer’s mutational sweet spot identified by Stanford researchers [Scope Blog] Our results suggest this nonlinear association is the consequence of a trade-off between the chance of acquiring a mutation that triggers the emergence of a new, fitter subpopulation and the risk of the mutation reducing the fitness of an already existing subpopulation.
CRISPR, The Revolutionary Gene-Editing Technique, Reveals Cancer’s Weaknesses [The Atlantic] CRISPR can finally tell us which human genes are essential—and which matter specifically to cancer cells.
	3. Prévention
Do potatoes reduce stomach cancer risk? [NHS Choices] The media seems to have gone with the slant that eating potatoes will decrease your risk of stomach cancer. But this was not a specific finding of this review, which actually found a reduced risk of stomach cancer was associated with a higher consumption of "white vegetables".
	3.1 Tabac
BBC Panorama’s tobacco industry revelations are genuinely shocking [Cancer Research UK] Notably, they’re alleged to have paid bribes to influence work at the World Health Organization’s Framework Convention on Tobacco Control, a United Nations campaign aimed at reducing deaths from tobacco-related illness that’s supported by the governments of 180 countries.
	4.1 Dép., diag. & prono. - Prostate
A patient’s perspective on recent prostate cancer screening news [HealthNewsReview] Reporting on active surveillance is critical because it is considered a credible approach to many, though not all, low-risk prostate cancers. It’s the treatment approach I’ve chosen, in consultation with a second urologist and an oncologist who specializes in prostate cancer.
	4.9 Dép., diag. & prono. - Sein
False Alarm Mammograms May Still Signal Higher Breast Cancer Risk [NPR] The study, done at several leading universities, looked back at more than 2.2 million screening mammograms considered to be false alarms between 1994 and 2009.
	5. Traitements
Complete surgical excision is the most effective treatment for breast implant-associated anaplastic large-cell lymphoma [MD Anderson Cancer Center] The current study, published in the Journal of Clinical Oncology, represents the most comprehensive study of BI-ALCL to date, including 30 investigators from 14 institutions across five continents.
	5.12 Immunothérapies
Interview CEO of Cellectis: CAR-T is not the Cancer Cure-All [Labiotech] CAR-T is solidifying in everybody’s mind as the next revolution in Cancer treatment. But there is still a lot to do…That’s basically what came out from my discussion with André Choulika, the CEO of the French CAR-T miracle Cellectis.
	5.2 Pharma
Puma preps its once-vaunted cancer drug for European submission [FierceBiotech] In the Phase III data disclosed at ASCO, Puma's drug led to severe diarrhea in about 40% of patients in the treatment arm, a consistent effect in neratinib's clinical program that analysts worry could be a debilitating flaw if and when the drug reaches the market.
	5.4 Traitements - Economie
What difference does bargaining make to drug prices? In Norway, up to 58% off [FiercePharma] Part of the explanation for the price differences is bargaining, according to the WSJ story. State-run health systems in Norway and other developed countries have the power to drive hard bargains with drugmakers, and they use it.
Bristol-Myers puts a blockbuster $142K price on new cancer med Empliciti [FiercePharma] That price tag puts the drug in line for potential blockbuster revenues, according to E.B. Capital Markets' Todd Campbell, who owns shares in rival Celgene. After all, the cost of Empliciti falls between that of Revlimid--at $14,000 per month--and the $9,000-per-month Velcade from Takeda.
	5.5 ASCO
2016 Cancer Survivorship Symposium Press Program to Feature New Insights for Patient Care After Cancer Treatment [ASCO] The 2016 Cancer Survivorship Symposium will take place January 15-16 at the San Francisco Marriott Marquis in San Francisco, California. Abstracts presented at this inaugural Symposium will focus on efforts to better understand the needs of millions of cancer survivors worldwide, and to develop comprehensive care models that meet those needs.
	6.1 Observation
China to Have Over 800,000 Lung Cancer Patients a Year by 2020, State Media Says [TIME] Air pollution is expected to replace smoking as the disease's primary cause.