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1. Biologie
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Many unexpected genetic variants hamper personalised medicine [Karolinska Institutet]
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In
recent decades much hope was based on the development of personalised
drug treatments, in which genetic tests determine the choice and optimal
dose of medication for each individual patient. However, the real
breakthrough is still to be seen, and now researchers at Karolinska
Institutet show in two separate scientific papers that many more gene
variants affect how a person responds to medication than previously
thought – and thus that today’s analytical tools are too coarse.
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2.11 Etiologie - Alimentation
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Watch our Google Hangout about meat and cancer risk [Cancer Research UK]
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We
were joined by two experts in this area – Dr Kathryn Bradbury from the
University of Oxford and Professor Owen Sansom from our Beatson
Institute in Glasgow – to explore the evidence that red and processed
meat are linked to an increased risk of cancer. We also talked about the
possible biological mechanisms behind a link, and discuss how people
can reduce their risk of cancer.
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3.1 Tabac
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Smoking 'linked to earlier menopause' [BBC News]
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Though
they cannot be certain of the long-term health consequences of these
findings, they point out that previous studies have linked earlier
menopause to a risk of earlier death. But early menopause has also been
associated with a lower risk of certain diseases, including breast
cancer.
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3.3 Prévention - Vaccins
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4. Dépistage, diagnostic et pronostic
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5. Traitements
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5.10 Traitements - Essais
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5.2.1 Pharma - Partenariats
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5.2.2 Pharma - Fusions & Acquisitions
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5.2.3 Pharma - économie
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5.3 Traitements - FDA, EMA,...
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5.3.4 Traitements - AMM (FDA, EMA)
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5.4 Traitements - Economie
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Kadcyla breast cancer drug 'too expensive' for NHS, says NICE [BBC News]
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The
final guidelines from NICE say the price tag per patient - £90,000 at
full cost - is not tenable. Manufacturer Roche says it offered a
discount - the same one it used to cut a deal with the Cancer Drugs
Fund. Women in England will still be able to get Kadcyla through this
fund for now.
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5.7.3 SABCS-AACR
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6.1 Observation
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6.6 Publications
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All about ORCID [The Scholarly Kitchen]
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Name
ambiguity is a huge problem in countries like Korea (where half the
population shares one of five last names) or Latin American countries,
where multiple family names are the norm. But we hadn’t predicted that
researchers in health and medical sciences would share this concern.
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6.9 Controverses
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Should patients be able to record their surgeries? [STAT]
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The
power of recordings gained widespread attention this year, when a
Virginia patient won a $500,000 malpractice suit after a secret audio
recording revealed his doctors made vicious comments about him while he
was sedated during a colonoscopy.
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