lundi 9 novembre 2015

Onco Actu du 9 novembre 2015

1. Biologie

TCGA renal papillary cell and prostate cancer [National Cancer Institute]

1.1 Biologie - Gènes

American Association for Cancer Research Launches International Genomic and Clinical Data-sharing Project [AACR]

Cancer researchers band together to pool tumor genome data [Science]

2.11 Etiologie - Alimentation

Barbecued meat may increase risk of kidney cancer [The Telegraph]

2.6 Etiologie - Environnement

Radon: the invisible gas that's a bigger killer than carbon monoxide [The Guardian]

2.8 Etiologie - Contraceptifs, THS

PR campaign underplays HRT cancer risks, critics say [The Guardian]

3. Prévention

First precision medicine trial in cancer prevention [PHG Foundation]

5.10 Traitements - Essais

Nivolumab in Renal-Cell Carcinoma [Now@NEJM]

5.12 Immunothérapies

The Hottest New Cancer Drugs Depend on Gut Microbes [The Atlantic]

5.9 AACR

New NTRK-targeted Therapy Shows Early Promise Against Tumors With NTRK Gene Fusions [AACR]

Mutant-IDH1 Inhibitor AG-120 Shows Early Promise Against Solid Tumors With IDH1 Mutations [AACR]

First-in-class Antibody-Drug Conjugate Shows Significant Clinical Benefit Against Metastatic Triple-negative Breast Cancer [AACR]

Osteoporosis Drug May Be Effective Against Pancreatic Cancer [AACR]

Analysis of Blood Samples Could Help Monitor Response of Colorectal Cancer Patients to BRAF Inhibitors [AACR]

New, Investigational PARP1/2 Inhibitor BGB-290 Shows Promise [AACR]

AZD9291 Shows Clinical Activity in Non-small Cell Lung Cancer Patients With Leptomeningeal Disease [AACR]

Loss of SMAD4 Gene in Certain Colorectal Cancers is Associated With Poor Prognosis [AACR]

Agios Extends Reach of Cancer Metabolism Drug into Solid Tumors [TheStreet]

​​Pediatric Low-grade Gliomas With CRAF Fusions May Require Differential and Combinatorial Targeted Therapies [AACR]

Adding Tivantinib to Standard Erlotinib Treatment Improved Outcomes for Specific Subgroup of Patients With Lung Cancer [AACR]

Investigational AKT Inhibitor AZD5363 is Active Against Multiple Tumor Types With AKT1 E17K Mutations [AACR]

ImmunoGen Refines Drug Targeting for Ovarian Cancer Patients [TheStreet]

6. Lutte contre les cancers

Transatlantic Dream Team of Top Researchers Selected To Tackle One of Cancer's Deadliest Forms: Pancreatic Cancer [AACR]

6.6 Publications

It's official: Anil Potti faked cancer research data, say Feds [Retraction Watch]

NIH metric that assesses article impact stirs debate [Nature News & Comment]

6.9 Controverses

It’s not a war on cancer that we need, it’s a revolution [The Cancer Blog]