Onco Actu du 2 novembre 2015

	2.11 Etiologie - Alimentation
News Analysis: So Will Processed Meat Give You Cancer? [NY Times] Dr. Ioannidis said his normal inclination would be to dismiss the meat and cancer link “as one of these 500 foods that have studies all over the place.” But in this case the link, while relatively tiny, he said, is consistent across many studies. “We could be wrong,” he added. “But my best interpretation is that there’s probably something there.”
Bacon fans embrace the hog on cancer report, but futures take fright [Reuters] Monday's WHO report is just the latest blow to the U.S. meat industry, which has seen a years-long downward trend of general red meat consumption in the country, despite the booming popularity of high-protein trends like the Paleo diet.
	3.1 Tabac
E-cigarettes: “Don’t let the genie out of the bottle” [Croakey] In paying tribute to the late Dr Nigel Gray, one of the leaders of tobacco control globally as well as in Australia, Professor David Hill warned that e-cigarettes may be the next flawed pursuit of “that illusory safe (or at least less dangerous) cigarette” as had been the development of low tar cigarettes in decades past.
	3.3 Prévention - Vaccins
Around a fifth of unvaccinated ethnic school girls think they don’t need HPV jab [Cancer Research UK] Researchers found that 17 per cent of girls from black backgrounds and 22 per cent of girls from Asian backgrounds who hadn’t been vaccinated said that they did not need the vaccination and the reasons they gave included that they did not expect to be sexually active before marriage.
	4. Dépistage, diagnostic et pronostic
Tumor RNA within platelets may help diagnose and classify cancer, identify treatment strategies [Massachusetts General Hospital] “By combining next-generation-sequencing gene expression profiles of platelet RNA with computational algorithms we developed, we were able to detect the presence of cancer with 96 percent accuracy.”
How scorpions became an unlikely ally in the fight against cancer [The Guardian] Based at the Fred Hutchinson Cancer Research Center in Seattle, Jim Olson leads a team whose biggest success is “tumour paint”, a drug that attaches to cancer cells, lighting them up so it is easier for surgeons to operate successfully.
	5. Traitements
Our milestones: How anastrozole became a number one hit [Cancer Research UK] In this instalment of our Milestones series, we look at Cancer Research UK’s pivotal trials, proving that a drug called anastrozole should be the gold standard for treating breast cancer in postmenopausal women.
Heat-triggered 'grenades' hit cancer [BBC News] The team plans to use liposomes - tiny bubbles of fat which carry materials round the body - to release toxic drugs when their temperature is raised.
High-power sound waves used to blast cancer cells [The Guardian] Guidance for the ultrasound beams is provided by magnetic resonance scanners that can focus the beams with millimetre precision ensuring only cancerous or damaged tissue is targeted. Healthy tissue is protected. The scanners also monitor the temperature of target cells to ensure they have been heated enough to kill them.
	5.12 Immunothérapies
Study success hints at pancreatic cancer immunotherapy promise [Cancer Research UK] Mice treated with the mesothelin-recognising T cells typically lived for 96 days after their cancer was first detected. That was nearly 80 per cent longer than the 54-day average for animals given T-cells designed to recognise a non-cancerous protein.
	5.3 Traitements - FDA, EMA,...
Daiichi Sankyo's cancer drug wins the FDA's coveted 'breakthrough' tag [FierceBiotech] The treatment, pexidartinib, is in development to treat a rare cancer of the tendons called tenosynovial giant cell tumor.
	5.3.4 Traitements - AMM (FDA, EMA)
FDA approves new therapy for pancreatic cancer [Pharmafile] Onivyde (irinotecan liposome injection) will be used as part of a combination regimen with two chemotherapy drugs, fluorouracil and leucovorin.
	5.4 Traitements - Economie
Final NICE 'no' for pancreatic cancer drug [PharmaTimes] Ali Stunt, chief executive at Pancreatic Cancer Action, called the decision “a travesty for patients and families”.
The Breast Cancer Market Will Capture Major-Market Sales of Almost $20 Billion in 2024, Driven by the Launch of Premium-Priced Therapies and Continued Uptake of Recent Entrants [PRNewswire] This growth will be fuelled by continued uptake of Roche/Genentech/Chugai's Perjeta (pertuzumab) and Kadcyla (trastuzumab-DM1) for HER2-positive disease, Pfizer's Ibrance (palbociclib) for hormone receptor (HR)-positive, HER2-negative disease, and the launch of several novel therapies, notably Roche/Genentech/Chugai's PD-L1 inhibitor, atezolizumab for triple-negative disease.
	6. Lutte contre les cancers
NCRI cancer conference day 1: prostate cancer drugs and early diagnosis [Cancer Research UK] For the next three days Liverpool will be home to some of the world’s top cancer experts for the annual National Cancer Research Institute (NCRI) conference. We’ll be blogging the highlights, and sharing updates on all the important talking points from the conference.
The Role of Clinical Studies for Pets with Naturally Occurring Tumors in Translational Cancer Research: Workshop Summary [The National Academies Press] In June 2015 the Institute of Medicine hosted a workshop to examine the rationale and potential for integrating clinical trials for pet patients with naturally occurring cancers into translational cancer research and development. Participants discussed the research needs, strategies, and resources to support greater integration of clinical trials for pets with cancer into translational research pathways, and challenges and potential solutions for facilitating that integration. This report summarizes the presentations and discussions from the workshop.
	6.1 Observation
Why is breast cancer becoming deadlier for black women? [The Guardian] The American Cancer Society’s report on rising rates among black women have researchers searching for answers in obesity, medical care and the environment.
200,000 cancer patients live in most deprived areas of England – study [The Guardian] Macmillan said the figures highlight the folly of the government’s plans to reduce the amount received by people entering the employment support allowance (ESA) work-related activity group – for people assessed as too ill to work but capable of taking steps towards employment – by about £30 a week.
Quarter of cancer patients dead in six months due to late diagnosis [The Telegraph] Nearly 90,000 people do not know they have got cancer until they arrive at Accident and Emergency wards, by which time only 36 per cent will live longer than a year.
Older people do not reject cancer treatment, study finds [The Telegraph] Too often, older people were not offered surgery and other potentially life-saving treatments because they were not properly assessed, with doctors simply assuming their age meant they were not strong enough to cope with treatment.
	6.10 Politiques
If Cancer Becomes Biden’s Cause, a Bold but Polarizing Doctor Is On Call [NY Times] In describing this “moonshot,” Mr. Biden was adopting language used by Dr. Soon-Shiong to describe his aspiration for cancer research. The two met for an hour in the White House just a few weeks ago, and Dr. Soon-Shiong gave the vice president a two-page outline of what he had in mind.
The Drug Discoverer - Putting off-patent drugs back to work [The Institute of Cancer Research] That’s what the Off-Patent Drugs Bill is all about – ensuring that where an off-patent drug is shown to be effective in a new way, a mechanism will exist for making sure it gets to patients.
	6.11 Patients
Notes From The 'Die-In,' A Demonstration For Metastatic Breast Cancer [Forbes] Before the demonstration ended, an organizer struck a chime 113 times, once for each U.S. person who would die that day from metastatic breast cancer. The ringing took several minutes; it seemed longer. A woman in a red shirt was crying. A teenage boy at the end of one of the die-in spokes, with earbuds, scrolled on his phone.
	6.8 Communication
A Growing Disenchantment With October ‘Pinkification’ [NY Times] Many women with breast cancer hate the spectacle. “I call it the puke campaign,” said Marlene McCarthy, the director of the Rhode Island Breast Cancer Coalition, who has metastatic breast cancer.