Onco Actu du 10 novembre 2015

	1. Biologie
Complex grammar of the genomic language [Karolinska Institutet] The findings, published in the journal Nature, explain why the human genome is so difficult to decipher – and contribute to the further understanding of how genetic differences affect the risk of developing diseases on an individual level.
‘Death clock’ in cells could tell you when you’ll get cancer [New Scientist] Stratton’s team believes signature one is a “mitotic clock”, a mutation that occurs as a result of cell division. “The rate of mutations correlate with the rate of cell turnover in tissues,” he says. “So in future we’ll be able to use the number of mutations from this signature to know how many times a cell has divided – giving us a deep insight into the biology of human tissues.”
	2.11 Etiologie - Alimentation
Increased meat consumption, especially when cooked at high temperatures, linked to elevated kidney cancer risk [MD Anderson Cancer Center] MD Anderson study also finds individuals with certain genetic variations more vulnerable to dietary risk.
	3.1 Tabac
E-cigarette regulations: How far should they go? [STAT] All experts agreed that e-cigarette regulations should include language about safety — the devices should be safe to operate, the liquid they use should be free from contaminants or toxins, and the devices and liquid containers should be childproof. Beyond that, a variety of suggestions are on the wish list.
	3.3 Prévention - Vaccins
HPV Vaccine Myth: Good Talks Needed [NY Times] Doctors sometimes promote the use of some vaccines with less enthusiasm than others. Sometimes, they don’t talk about them at all.
	4.1 Dép., diag. & prono. - Prostate
New test for prostate cancer significantly improves screening [Karolinska Institutet] The study, which is presented in The Lancet Oncology, included 58,818 men from Stockholm aged 50 to 69 and was conducted between 2012 and 2014. The STHLM3 test and PSA were performed on all participants and then compared.
	5.12 Immunothérapies
Gut microbes fuel effectiveness of anti-CTLA-4 cancer immunotherapy. Part I [NIHilist's Immunology] In all, based on this paper we can't say how microbes help anti-CTLA-4 and how much this "help" is meaningful in clinical settings.
	5.2 Pharma
Agios slips on mixed solid tumor data for its Celgene-partnered cancer drug [FierceBiotech] AG-120, like all of Agios' cancer candidates, is designed to starve malignant cells by targeting the enzymes they need to metabolize nutrients.
	5.4 Traitements - Economie
Idiocy On Drug Research Costs [In the Pipeline] Here’s a piece from the Center for Economic and Policy Research that claims to have the whole high-drug-price problem figured out. It’s “incredibly inefficient research”, just so you know.
	5.9 AACR
Q&A With Kimberly Stegmaier, MD, on Pediatric Cancer Research [CANCER RESEARCH Catalyst] The meeting is titled, “Advances in Pediatric Cancer Research: From Mechanisms and Models to Treatment and Survivorship.” What is the significance of “From Mechanisms and Models to Treatment and Survivorship,” and how does it reflect the status of the field?
	6. Lutte contre les cancers
Book Review: DeVita's History of Oncology Told with Candor and Optimism [The Cancer Letter] In scientific terms, Siddhartha Mukherjee’s book has the limitations of a retrospective study; Vince DeVita’s book is more like a prospective clinical trial.
DeVita: 50 Years of Stories On Cancer Wars and Skirmishes [The Cancer Letter] DeVita, 80, served as director of the NCI from 1980 to 1988.
	6.1 Observation
Mouth cancer now the tenth most common cancer in men [Cancer Research UK] The incidence rate of the disease has increased by a third over ten years, rising from 9 per 100,000 people in 2002 to 12 per 100,000 in 2012.
	6.11 Patients
The moment medical students discover a profound appreciation for humanity [Cancer World] A great short piece by medical student Armaan Rowther flagging up the role of anatomy labs in shaping medics attitudes towards their future patients.
	6.2 Implants mammaires
Silicone breast implants still lack proof of safety [Reuters] Good evidence on the safety of silicone gel breast implants is still lacking almost 10 years after they were reintroduced to the U.S. market, researchers report in the Annals of Internal Medicine.
	6.6 Publications
Scientist falsified data for cancer research once described as ‘holy grail,’ feds say [Washington Post] The false data, said the report, were used for papers in nine journals, including the New England Journal, Nature Medicine, the Journal of the American Medical Association and Lancet Oncology, all of the articles since retracted.
Potti found guilty of research misconduct [Science] Eight years after questions were first raised about the work of Duke University cancer researcher Anil Potti, federal officials have found Potti guilty of research misconduct. The findings bring to a close one of the most egregious U.S. scientific misconduct cases in recent years.