Onco Actu du 27 octobre 2015

	0. A la Une
Australians should limit but not stop red meat intake, say experts [The Guardian] Agriculture minister Barnaby Joyce said Australians should not be concerned by the WHO research. “If you got everything that the WHO said were carcinogenic and took it out of your daily requirements, well, you are kind of heading back to a cave,” he told ABC radio.
How Red Meat Joined the 478 Other Things That Might Give You Cancer [Bloomberg] Even though WHO has determined that red meat is a carcinogen, the report doesn’t quantify how much meat it would take to cross into the danger zone.
Red meat is strongly linked to cancer [11 janvier 2005 - Nature News] Diet experts urge move to poultry, fish and beans after results of long-term study.
WHO report: Red meat linked to cancer – Expert reaction [New Zealand Science Media Centre] Prof Lynnette Ferguson, Professor of Nutrition, Auckland Cancer Society Research Centre, University of Auckland, comments:“It is not like cigarette smoking where there is no question that taking up cigarette smoking is dangerous. There is no question that eating a solidly red and processed meat diet is dangerous – but that’s not the way people eat. It isn’t really in the same category and I think that is one of the misunderstandings that is coming out."
WHO Review Links Red and Processed Meats to Cancer [ACS] Based on earlier scientific studies, including findings from the American Cancer Society’s Cancer Prevention Study II, the American Cancer Society has recommended limiting consumption of red and processed meat specifically since 2002.
Red Meats Linked to Cancer, Global Health Group Says [Wall Street Journal] The conclusions by the agency “defy both common sense and dozens of studies showing no correlation between meat and cancer and other studies showing the many health benefits of balanced diets that include meat,” said the North American Meat Institute.
Processed meat and cancer – what you need to know [Cancer Research UK] Let’s be clear: yes, a prolonged high-meat diet isn’t terribly good for you. But a steak, bacon sandwich or sausage bap a few times a week probably isn’t much to worry about. And overall the risks are much lower than for other things linked to cancer – such as smoking.
Five questions about the WHO’s cancer-causing meat announcement answered [The Globe & Mail] The key is finding a balance of how to manage potential risks, says Sian Bevan, director of research at the Canadian Cancer Society. “It’s important to remember it’s a relative risk,” she said. “An individual’s personal risk [for colorectal cancer] is already relatively low.”
Italy's Parma ham connoisseurs defend prosciutto amid processed meat scare [The Guardian] “Prosciutto di Parma isn’t a processed meat or a sausage, but a product that is matured over a long period of time,” the Guardian was told by a spokesperson for the Parma Ham Consortium, a 55-year-old organisation of producers who use and safeguard the traditional processing method used in what is a staple of Italian kitchen tables.
The Guardian view on meat and cancer: a little of what you fancy will do you no harm [The Guardian] It’s certainly not worth worrying about too much. On the other hand, there are no grounds for sympathy with “Big Calorie”, the agribusiness lobby, which would have us eat far more of everything than is good for us, and which profits from animal cruelty on a literally industrial scale.
Does bacon cause cancer? Key questions about the WHO red meat report [The Telegraph] If no one in the UK smoked, it would mean 64,500 fewer cases of cancer each year. A ban on all red and processed meats, would mean just 8,800 fewer cases.
Food industry greets cancer links with a shrug – it's been here before [The Guardian] So while there may be a jolt to sales in the next few days and weeks as some shoppers ponder whether to pick up a packet of salmon rather than smoked bacon, history suggests that eventually households fall back to their own personal preferences.
Argentinians react to report linking meat to cancer: 'I'd rather die than give it up' [The Guardian] The country is no longer in the world’s top five beef-producing countries and its appetite for beef has actually fallen by almost half compared to 50 years ago and is now challenged by Hong Kong, Uruguay and Luxembourg. But Katunaric says it is still central to Argentinian life.
Processed meat can cause cancer, red meat probably can: WHO [Reuters] The news prompted animal rights activists People for the Ethical Treatment of Animals to offer free vegan diet starter kits and outraged agriculture groups.
Processed meat: your animated guide to what is a carcinogen - video [The Guardian] Confused about what you can still eat? Here’s our quick rundown of the World Health Organisation’s new evidence on which kind of meats present a cancer risk
Report Links Some Types of Cancer With Processed or Red Meat [NY Times] But James Coughlin, a nutritional toxicologist and a consultant for the National Cattlemen’s Beef Association, said the panel’s conclusions were based on “weak associations” that did not support its overall conclusions. He pointed out that even the panel itself was divided on the issue: Of 22 members who voted on its conclusions, seven either disagreed or chose to abstain.
	3.1 Tabac
E-cigarettes: a consumer-led revolution [The Guardian] E-cigarettes are used by millions in the UK, but information about them is sometimes conflicting. So what is the current evidence on them?
	5. Traitements
Large-scale screen of drug combinations identifies potential treatment for resistant, BRAF-mutant melanoma [Massachusetts General Hospital] Combining drugs addressing different signaling pathways has synergistic effect in tumors resistant to BRAF inhibition.
Are progression-free and disease-free survival the new gold standard for cancer trials? [Cancer World] Showing that a new drug can keep advanced cancers from progressing, or stop early cancers from returning, is quicker, cheaper and easier than showing that it helps patients live longer. But how can we judge in which instances these surrogates will accurately predict overall survival?
	5.10 Traitements - Essais
Merck's star oncology drug posts mixed results in a lung cancer trial [FierceBiotech] Both levels of Keytruda posted a statistically significant improvement in overall survival, Merck said, but failed to reach that mark on the measure of progression-free survival for the whole population.
Merck’s KEYTRUDA® (pembrolizumab) Shows Superior Overall Survival Compared to Chemotherapy in Patients with Previously Treated Advanced Non-Small Cell Lung Cancer Whose Tumors Express PD-L1 [Merck] Merck Plans Regulatory Submissions in the U.S. in late 2015 and in the European Union in Early 2016.
Merck's Keytruda extends survival in lung cancer study [Reuters] Wall Street analysts expect cancer immunotherapies to earn combined annual sales of over $20 billion by 2020.
	5.3 Traitements - FDA, EMA,...
EMA Adopts a Positive Opinion Recommending to Extend Therapeutic Indications for Crizotinib [ESMO] New indication concerns the first-line treatment of adults with ALK-positive advanced NSCLC.
	6. Lutte contre les cancers
First precision medicine centres of excellence announced [Pharma Times] Belfast, Cardiff, Glasgow, Leeds, Manchester and Oxford will host the centres, which will act as a hub for regional precision medicine activities within the UK-wide network, co-ordinated from the Cambridge headquarters.
	6.1 Observation
Why People With Metastatic Breast Cancer Want To Get Counted [Forbes] As things stand, doctors can’t say what proportion with early-stage disease will recur (a controversial statistic, to be considered separately). They don’t know, on average, or based on the breast cancer subtype or otherwise, how long people are likely to live after a recurrent, stage 4 breast cancer diagnosis.
	6.4 Médico-éco
Cancer diagnosis brings income loss for families [Reuters] The researchers found that after a cancer diagnosis, hours worked decreased by about 200 hours, or five full-time weeks. Annual labor market earnings dropped 40 percent over the first two years and remained lower than before cancer diagnosis, though total family income often recovered within four years, the study team reported in the journal Cancer
	6.6 Publications
Auto-Update Has Arrived! ORCID Records Move to the Next Level [ORCID] Researchers frequently ask, “Why, if I include my ORCID iD when I submit a manuscript or dataset, isn’t my ORCID record “automagically” updated when the work is published?” With the launch of Auto-Update, that is just what will happen.