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1. Biologie
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2. Etiologie
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4. Dépistage, diagnostic et pronostic
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Podcast: Dr. Otis Brawley on "pathologic profiling" [HealthNewsReview]
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Despite
many advances in studying cancer, we still use a definition of cancer
from the 1850s. That’s what Dr. Otis Brawley, chief medical officer of
the American Cancer Society, told the recent Preventing Overdiagnosis
2015 conference at the National Institutes of Health. As a result, he
says, the belief continues that a cancer will kill because it looks like
other cancers that spread and killed in the 1850s (audio - 16 mn).
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5.12 Immunothérapies
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Cancer Immunotherapy: The Cutting Edge Gets Sharper [Scientific American]
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It
was standing room only for many of the presentations at the first
International Cancer Immunotherapy Conference, which took place from
September 16 to 19. Speaker after speaker started their talks by
disclosing financial ties to a variety of companies ranging from
pharmaceutical giants to their own start-ups.
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5.2.1 Pharma - Partenariats
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5.3 Traitements - FDA, EMA,...
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5.3.4 Traitements - AMM (FDA, EMA)
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Nivolumab in combination with ipilimumab [FDA]
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Approval
was based on demonstration of an increase in the objective response
rate (ORR), prolonged response durations, and improvement in
progression-free survival (PFS) in an international, multicenter,
double-blind, randomized, two-arm, active-controlled trial in patients
who were previously untreated for unresectable or metastatic, BRAF V600
wild-type melanoma.
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FDA approves Bristol-Myers drug combination for skin cancer [Reuters]
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Four
doses of the combination would cost $141,000, about 6 percent more than
the cost of Yervoy alone. Those who respond to the combination would
continue receiving Opdivo alone, bringing the cost for a year of
treatment to $256,000, a Bristol-Myers spokeswoman told Reuters.
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5.4 Traitements - Economie
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6. Lutte contre les cancers
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Rising Cancer Rates Threaten Economic Stability [ACS]
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Authored
by researchers from the International Agency for Research on Cancer
(IARC), the American Cancer Society, and Imperial College of London, the
commentary says in the absence of the implementation of prevention,
LMICs will not have the resources to diagnose and treat all new cancer
patients, and the economic burden will soon become unsustainable. The
commentary appears in the Journal of the National Cancer Institute
(JNCI).
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6.1 Observation
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Doctors often overtreat with radiation in late-stage lung cancer [UIC]
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The
new analysis looked at 47,000 patients who received palliative
radiation for stage 4 lung cancer in the U.S. between 2004 and 2012 and
found that about one in five had received chemotherapy at the same time.
Nearly a third of patients received more than 25 radiation treatments —
10 above the recommended maximum.
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6.11 Patients
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Well: Living With Cancer: My Doctor, My Friend [NY Times]
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When
my situation took a decided downturn, Dr. Matei arrived at the infusion
room, plunked herself on the floor by my feet, and mournfully said,
“You are my worst-doing patient.” She was doing her best, to no avail.
At that moment, paradoxically, she became my friend.
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