Onco Actu du 13 octobre 2015

	1. Biologie
Scientists uncover four different types of bowel cancer [The Institute of Cancer Research] Researchers believe that the most immediate implication of their findings will be to help identify patients at risk of developing more serious, fast-growing disease that requires more intensive treatment.
Prostate cells undergo 'reprogramming' to form tumors, study finds [Dana-Farber Cancer Institute] Scientists have gained a key insight into how prostate tumors get their start – not by rewriting the normal DNA code, but by reprogramming the master regulator of genes in prostate cells to drive malignant growth.
Biomedical researchers lax in checking for imposter cell lines [Nature News & Comment] More than half of biomedical researchers say that they do not bother to verify the identity of their cell lines, a survey1 suggests — even though scientists have been warned for years that many studies are undermined because the cells they use are contaminated or mislabelled.
Bowel cancer is four distinct diseases [BBC News] They looked at laboratory and clinical data from more than 3,000 patients with bowel cancer to see if they could better classify the disease. Nearly all of the tumours could be sorted into the four groups.
	2.5 Etiologie - Gènes
Q&A: The Roots of BRCA1 Mutations for Ashkenazi Jews [NY Times] BRCA1 mutations are not the only problem with a much higher incidence among Ashkenazi Jews, the National Cancer Institute says. Harmful mutations in the BRCA2 gene are also more prevalent in that population in the United States, as well as in other groups around the world, like Norwegian, Dutch and Icelandic people.
	3.1 Tabac
Global Health: Study Shows Spread of Cigarettes in China [NY Times] Chinese men now smoke one-third of all the world’s cigarettes, and a third of all young men in China are doomed to eventually die from the habit, scientists in China and Britain have concluded.
	5.2 Pharma
Merck KGaA bets on cancer drugs to revitalize German firm [Reuters] Luciano Rossetti, head of global research and development at Merck's biopharma business Merck Serono, said the company is in a "rapid evolution", with up to 80 percent of its pipeline focused on oncology and immuno-oncology.
	5.3 Traitements - FDA, EMA,...
Collecting high-quality information on medicines through patient registries [EMA] The European Medicines Agency (EMA) has launched an initiative on patient registries aimed at making better use of existing registries as a source of high-quality post-authorisation data for regulatory decision-making, and to facilitate the establishment of new registries if needed.
	6. Lutte contre les cancers
Computer training may improve memory for childhood cancer survivors [Reuters] On average, the participants were 12 years old, and had completed cancer treatment about five years earlier. They were randomly separated into two groups, one receiving the computer training program, another put on a “waitlist” to serve as a comparison.
	6.1 Observation
Blood clots contribute to deaths of 4,000 cancer patients a year, MPs warn [The Guardian] “It is not always widely known that cancer patients have a four- to sevenfold increased risk of developing a blood clot compared with the general population,” said Eve Knight, co-founder and chief executive of AntiCoagulation Europe.
	6.11 Patients
You need a lot of luck, not just positivity, when cancer strikes [The Guardian] Lynch’s cancer was too aggressive to be halted by the intelligence, chutzpah and fine character of its host. As all cancers are, despite the endless references to deaths occurring “despite a brave fight”.
	6.3 Associations
World's largest cancer charity lays out field's grand challenges [Nature News & Comment] How can you distinguish between deadly cancers that need treatment and benign cancers that do not? Can unknown carcinogens be identified by the molecular fingerprints that they leave in tumours? Could vaccines be used to prevent more cancers? The world’s largest cancer charity hopes to find out.