Onco Actu du 16 septembre 2015

	1. Biologie
Targeting cancer’s self-defence mechanisms [Cancer Research UK] The new science that studies the ways in which cells control their gene activity patterns – and adapt them in response to their environment – is known as epigenetics. This is now a hot topic for many researchers around the world, including our Cancer Research UK-funded lab at the University of Birmingham.
Cancer Metastasis: Trying to Catch the Culprits Earlier [NIH Director's Blog] In the near-term, basic research using tumor cells isolated by these scaffolds will help to advance understanding of the complex factors involved in cancer metastasis. A bit further down the road, such cells may also reveal new strategies for detecting cancer, tracking the effectiveness of therapies, developing new molecularly targeted treatments, and identifying more precise, individualized ways of using drugs and combinations of therapies.
	2.6 Etiologie - Environnement
Indoor pesticide exposure tied to childhood cancers [Reuters] The link between outdoor exposure and childhood cancers was not as strong as for indoor exposure, because people tend to spray more pesticides indoors, Lu said.
	3.1 Tabac
De-mystifying Stop Smoking Services [Cancer Research UK] Stop Smoking Services offer a variety of options to help you quit and keep yourself on track, including prescription medication like NRTs and Champix, free carbon monoxide testing to monitor your progress, and weekly support and advice.
Experts criticise Public Health England e-cigarettes review [The Guardian] Experts writing in the British Medical Journal (BMJ) joined the Lancet in criticising the evidence used by Public Health England (PHE) in its report on e-cigarettes.
F.D.A Orders R.J Reynolds to Stop Selling 4 Cigarette Products [NY Times] Under a 2009 federal law, the F.D.A. can reject cigarettes and other tobacco products that its scientists believe pose greater public health risks than comparable products on the market, a sharp departure from previous practice, when tobacco companies could change existing products and introduce new ones at will.
	4.10 Dép., diag. & prono. - Poumon
Study Defines Criteria for MET-driven Lung Cancer Suitable for Crizotinib Treatment [ESMO] A study presented at the 16th WCLC sheds light on the best method to determine the threshold at which MET amplification becomes clinically relevant.
	4.2 Dép., diag. & prono. - Génome
Using Genetic Sequencing to Manage Cancer in Children [NIH Research Matters] The researchers note several limitations with the study. Since there wasn’t a control group, they couldn’t assess whether the approach resulted in improved outcomes. The sequencing cost—which was covered under the research protocol—was about $6,000 per patient.
	5.2.1 Pharma - Partenariats
MD Anderson, Cayman Chemical, and Fannin Innovation Studio form therapeutics company [MD Anderson Cancer Center] The pre-clinical therapeutics company is dedicated to discovering and developing novel small molecule inhibitors for the treatment of a variety of inflammation-induced cancers, including melanoma and colon and pancreatic cancer.
	5.2.2 Pharma - Fusions & Acquisitions
Roche says biotech 'bubble' pushes midsize buys out of reach [Reuters] "This whole segment is overvalued. The more time goes by, the more I am worried that this whole thing will collapse at some point and it will not be not good for the industry if there is too much volatility," he said.
	5.3 Traitements - FDA, EMA,...
Cardiologist Nominated to Be Head of F.D.A. [NY Times] Dr. Califf became the deputy commissioner for medical products and tobacco at the F.D.A. in March. If his nomination is confirmed, Dr. Califf will be taking the helm of one of the most far-reaching federal agencies.
	5.4 Traitements - Economie
Science Talk - Five key points on cancer drug pricing [The Institute of Cancer Research] We’ve said before that drugs cannot command unlimited prices – and that generally NICE does a very good job in the unenviable positon of putting a cost on human life.
	5.8 ASH
ASH Meeting on Hematologic Malignancies Provides Important Clinical Updates [ASH] To best convey the optimal use of these new agents and techniques in patient care, the ASH Meeting on Hematologic Malignancies will follow a case-based discussion format focusing on real-life examples from top international experts.
	6. Lutte contre les cancers
Brazil’s cancer curse [Mosaic] “That means that the population of south and south-eastern Brazil has an immense number of Li–Fraumeni carriers, probably more than 300,000,” says Achatz. “People are just not aware of this, so probably many cancers that are occurring in the population in general are due to this mutation and people just don’t realise.”
	6.10 Politiques
American Association for Cancer Research National Survey Shows 74 Percent of Voters Want More Federal Funding for Cancer Research [AACR] New AACR Cancer Progress Report highlights the lifesaving advances that federal funding has made possible.
	6.7 DMP, Big Data & applis
Doctors barred from discussing safety glitches in U.S.-funded software [POLITICO] Critics say the clauses – which POLITICO documented in contracts with Epic Systems, Cerner, Siemens (now part of Cerner), Allscripts, eClinicalWorks and Meditech – have kept researchers from understanding the scope of the failures.
Imprecision Medicine: Eric Dishman Kicked Off the Converged IT Summit [Bio-IT World] Data management will be a huge stumbling block, Dishman conceded. If we start just by sequencing the new cancer patients each year at a terabyte of sequence data each, we will generate four exabtyes of new data annually, data that will need to be stored, analyzed, and securely shared.
ASCO Calls on Congress to Enact Legislation to Ensure Widespread Interoperability of Electronic Health Records and Prohibit Information Blocking [ASCO] "The promise of EHRs will never be realized until we achieve interoperability and are able to share data in a safe and secure way."