Onco Actu du 15 septembre 2015

	1. Biologie
Eye gene acts as ‘partner in crime’ in leukaemia mystery case [Cancer Research UK] We found a particular eye gene, called FOXC1, that is switched on in around one in five patients with a type of blood cancer called acute myeloid leukaemia (AML). And, being an ‘eye’ gene, you may have guessed that this is a bit strange.
	2.6 Etiologie - Environnement
Pesticide exposure linked to childhood cancer, lower IQ [CNN] This analysis "is confirming that pesticides may play a role, possibly a significant role, in the development of childhood leukemia and lymphoma," Lu said. However, he added that it is hard to say at this point if exposure to these chemicals is definitely a risk factor for these cancers.
	3. Prévention
Mediterranean diet with extra olive oil cuts breast cancer risk by 68 per cent [The Telegraph] Dr Miguel Martínez-González and his team followed more than 4,200 women who were either on a low fat diet or a Mediterranean Diet supplemented with extra olive oil, for five years.
Mediterranean diet plus olive oil may reduce breast cancer risk [Reuters] Over the course of the study, there were 17 confirmed diagnoses of breast cancer in the low-fat comparison group, 10 in the Mediterranean diet with nuts group and eight in the Mediterranean diet with olive oil group, the researchers found.
	3.1 Tabac
Smoking ban in cars with children campaign launched [BBC News] Billboards and posters will highlight the ban, intended to protect under 18-year olds from second-hand smoke.
	3.4.1 Chimioprévention - aspirine
Well: In a First, Aspirin Is Recommended to Fight a Form of Cancer [NY Times] The guideline for those at high risk of the disease, published Monday in a draft report from the United States Preventive Services Task Force, is the first time a major American medical organization has issued a broad recommendation to take aspirin to prevent a form of cancer.
	4.2 Dép., diag. & prono. - Génome
Broad Institute named as one of two national genome characterization centers [Broad Institute of MIT and Harvard] As part of the NCI effort the Broad Institute will sequence patient tumors to accelerate the development of effective treatments to fight the disease.
	5. Traitements
Combining Epigenetic Therapies With Immunotherapies is Likely to Improve Outcomes for Cancer Patients [AACR] The review article also provides a comprehensive overview of all ongoing clinical trials that are evaluating combinations of epigenetic drugs and immunotherapy against many cancer types, including leukemias, metastatic melanoma, metastatic kidney cancer, peripheral neuroectodermal tumors, non-small cell lung cancer, and metastatic colorectal cancer.
	5.2 Pharma
Patrick Soon-Shiong plucks another cancer drug out of Amgen's pipeline [FierceBiotech] Soon-Shiong's NantPharma has in-licensed Amgen's AMG 337, a mid-stage MET inhibitor in the clinic for gastric cancer.
	5.3 Traitements - FDA, EMA,...
ERYTECH submits EMA Marketing Authorization Application for GRASPA to treat acute lymphoblastic leukemia [Erytech] The MAA for GRASPA, ERYTECH’s lead product, consisting of asparaginase encapsulated in red blood cells, is based on the positive findings of the pivotal GRASPALL 2009-06 Phase 2/3 study in children and adults with relapsed ALL.
AbbVie Announces Submission of a Supplemental New Drug Application for IMBRUVICA® (ibrutinib) for Treatment-Naive Chronic Lymphocytic Leukemia [AbbVie] The trial enrolled 269 treatment-naive patients with CLL or small lymphocytic lymphoma (SLL) aged 65 years or older in the U.S., EU and other regions. Patients were randomized to receive either ibrutinib 420 mg orally, once daily until progression or unacceptable toxicity, or chlorambucil on days 1 and 15 of each 28-day cycle for up to 12 cycles.
	5.4 Traitements - Economie
Counting the true cost of the Cancer Drugs Fund cuts [Pharmafile] The potential vicious circle of patients losing access to vital medications and companies abandoning clinical trials England for more profitable shores is a worrying development, and only time will tell to what extent English cancer patients will suffer as a result.
Drug price watchdog may be new threat to industry’s high priced medicines [The Boston Globe] Group says top priority is value, not what the market will bear.
	6.11 Patients
I have cancer in my 20s. How am I supposed to cope? [The Guardian] Facing the unknown is petrifying. How does six months or more off work affect my chances of securing that job I so desperately want? Will I still want it at the end of this? Will I always be a cancer patient? Do I need to always tell people what I have experienced? How do I live with this? Do you get past this?
	6.3 Associations
Cancer Research UK launches three new funding schemes for cancer doctors [Cancer Research UK] Over the next few years, the charity’s Clinical Careers Committee hopes to fund twice as many fellowships as were previously available. And three schemes will be available for clinicians at different stages of their careers.
	6.4 Médico-éco
International Longevity Centre - UK investigates cancer’s cost to the UK economy [ILCUK] Rethinking Cancer finds that if employment rates for cancer survivors were the same as for the rest of the population cancer survivors would contribute an additional £4 billion to the UK economy each year.