Onco Actu du 26 août 2015

	1. Biologie
Electrical Control of Cancer Cells Described [GEN] "Beyond the immediate relevance to K-Ras in cancer, it is a completely new way that cells can use electrical charge to control a multitude of signaling pathways, which may be particularly relevant to the nervous system.”
	4.2 Dép., diag. & prono. - Génome
New Moffitt Cancer Center Study Finds Young Black Women Have a Higher Frequency of BRCA Mutations Than Previously Reported [Moffitt] “Our results suggest that it may be appropriate to recommend BRCA testing in all black women with invasive breast cancer diagnosed at or below age 50.”
	4.5 Dép., diag. & prono. - Colorectal
New Blood Test for Colon Cancer Improves Colonoscopy Screening Results [The Optical Society] Optical Raman Spectra of Blood Shows Simple Fingerprint for Cancerous Growth and Precancerous Polyps.
	5. Traitements
Promising class of new cancer drugs causes memory loss in mice [The Rockefeller University] The findings will likely fuel more research into the brain effects of BET inhibitors, and could lead to the development of safer drugs that reduce the risk of potential side effects such as memory loss.
New DCIS study, news release lead to (very) mixed messages: 'And we wonder why patients get confused' [HealthNewsReview] A news release published by Dr. Narod’s institution declared “Ductal carcinoma in situ carries a higher risk of death than previously thought,” and it took a decidedly different tack than the NYTimes‘ angle.
	5.2.1 Pharma - Partenariats
Immatics, MD Anderson partner on a $60M immuno-oncology T-cell spinout [FierceBiotech]
	5.3 Traitements - FDA, EMA,...
Nine Explanations For Why The FDA Is Approving Almost Every New Drug Application [Forbes] If 96% of applications for brand new drugs are getting through, it’s hard not to suspect that we’re getting close to the “too much” end of the pendulum.
	6. Lutte contre les cancers
Could proton beam therapy help cure the UK's toughest cancers? [The Guardian] The transformation of Manchester into a cancer top player represents five years of canny collaboration (including a £30m joint recruitment programme) between the Christie and the university, driven by the fact that Manchester’s population has one of the worst cancer records in the country.
	6.1 Observation
Relapse, poor survival in acute leukemia linked to genetic mutations that persist in remission ​​​[WUSTL] Using genetic profiling to study bone marrow samples from patients with acute myeloid leukemia (AML), researchers found that those whose cells still carried mutations 30 days after the initiation of chemotherapy were about three times more likely to relapse and die than patients whose bone marrow was cleared of these mutations.
	6.10 Politiques
Prescription drug prices becoming presidential campaign issue [The Boston Globe] On the campaign trail, most candidates have shied away from the subject, but there are signs that might not last.