Onco Actu du 3 juillet 2015

	2. Etiologie
Orange juice and grapefruit linked to melanoma skin cancer [NHS Choices] A positive association was seen for those who had higher sunburn susceptibility as a child, more blistering sunburn episodes, spent more time in direct sunlight, and those with a higher annual UV flux at their home. This may have been the cause of the increased melanoma risk rather than the effect of citrus fruit.
	2.5 Etiologie - Gènes
Competition Spurs Research on Breast Cancer Genomics and Risk [National Cancer Institute] The innovative use of GWAS data can point to new research directions that can better identify women at increased risk of breast cancer and guide efforts to improve prevention and early detection, the competition organizers believe.
	3.1 Tabac
Cancer Survivors Who Smoke Perceive Less Risk from Tobacco than Non-Smoking Survivors [ACS] For their new study, researchers led by Lee Westmaas examined psychological correlates of smoking status and patterns, likelihood of quitting, and intentions to quit among long-term survivors enrolled in the American Cancer Society’s Study of Cancer Survivors–I (SCS-I), a longitudinal nationwide study of adult survivors of 10 commonly diagnosed cancers.
Healthcare students often uninformed about smoking dangers, cessation [Reuters] “The most concerning finding might be the degree to which this lack of knowledge is increasing over time.”
	3.5 Prévention - UV
Indoor tanning not limited to tanning salons [Reuters] Of those who had ever tanned indoors, about two in five said they had done so outside of a tanning salon, most often at a gym or health club, beauty shop or private home.
	4.12 Biopsies liquides
Fishing for clues – how ‘liquid biopsies’ are uncovering cancer’s secrets [Cancer Research UK] The team’s work is part of a fast-flowing area of research, moving away from a need for invasive tissue samples, called biopsies, to gather precious research material. Instead, they’re turning to blood-based ‘liquid biopsies’ – searching for crucial information floating in a patient’s blood.
	5. Traitements
New Drug Conjugate Suggests Promise against Sarcoma [National Cancer Institute] Led by NCI researchers, the study showed that the drug conjugate, called STA-12-8666, completely eradicated tumors in mice with Ewing sarcoma and rhabdomyosarcoma.
	5.2 Pharma
Exelixis Provides Update on Genentech’s Pending New Drug Application for Cobimetinib, an Exelixis-Discovered Compound [Exelixis] FDA extended its review after Genentech submitted, at FDA request, additional data from coBRIM, the phase 3 registrational trial of cobimetinib and vemurafenib in patients with BRAF V600 mutation-positive advanced melanoma.
	5.2.1 Pharma - Partenariats
Kite, Leukemia & Lymphoma Society Partner to Develop Drug Candidate [GEN] The Leukemia & Lymphoma Society (LLS) will partner with Kite Pharma in developing the company’s lead product candidate KTE-C19 for patients with refractory aggressive non-Hodgkin lymphoma.
CAR-T Therapies Get $1 Billion Boost [The Scientist] The biotech firm Celgene inks a huge collaboration deal with Juno Therapeutics to develop and commercialize new cancer immunotherapies.
	5.2.3 Pharma - économie
Chris Viehbacher's Two Billion Dollars [In the Pipeline] Even large companies have good people working at them - believe it or not! And some of them even have good ideas, too. But it can be harder for them to make headway in a large organization, he is right about that.
	5.3 Traitements - FDA, EMA,...
Cancer immunotherapy approved in UK [BBC News] Nivolumab was one of the drugs labelled a "milestone" therapy at a major cancer conference last month. It has now been approved through the UK's Early Access to Medicines Scheme, which fast-tracks promising new therapies.
	5.4 Traitements - Economie
Ever higher cancer drug prices—driven by US policies and genetic sequencing [BMJ Blogs] Ramsey suggests that the most profound factor fuelling cancer drug prices has been technology, specifically the rapid decline in the cost of sequencing the human genome.
Personalized Medicine, Targeted Therapeutics & Companion Diagnostic Market to 2019 [Life Science Industry Research] The report is supported by over 317 tables & figures over 279 pages.
	5.5 ASCO
Advances in Immunotherapy Stand Out During a Highly Influential ASCO 2015 [The OBR Blog] Nearly half the oncologists surveyed on the impact of this year’s American Society of Clinical Oncology meeting said they were likely to make changes in patient treatment based on what they learned during the five-day conference. Forty-nine percent of oncologists said they were very likely or extremely likely to alter treatment strategies, as compared to 24% surveyed last year.
	6. Lutte contre les cancers
Our new Pioneer Awards funding scheme – high-risk, high-reward, high-impact [Cancer Research UK ] We won’t require extensive, lengthy documentation up front – just a two-side outline of the idea, submitted anonymously, and why it will make a real difference in cancer. The Committee will short-list the ideas they receive on a regular basis, and successful applicants will then be invited to pitch their idea, in person, to the panel.
NIH VideoCast - Precision Medicine Initiative Working Group Meeting - July 2015 (Day 1) [NIH] The workshop focuses on the design of an inclusive cohort, building and sustaining public trust, direct-from-participant data provision, and effective and active participant engagement characteristics of a national research cohort of one million or more volunteers.
Lowy's First Director's Report to Advisory Panel [The Cancer Letter] The following is a transcript of NCI Acting Director Douglas Lowy’s remarks to the joint meeting of the National Cancer Advisory Board and the NCI Board of Scientific Advisors.
How Precision Medicine Will Transform Cancer Treatment [Video] [Scientific American] Cancers, revered researcher Harold Varmus told me today, are like snowflakes, each one unique. But cancers also belong to families, and members of those families share vulnerabilities—genetic weak spots that scientists are learning to target with increasing precision.
	6.1 Observation
Urologist calls attention to implications of flawed prostate specific antigen data in SEER [ecancer - News] The PSA data were removed after quality control checks revealed that a substantial number of PSA values included in the programmes were incorrect.
Women’s lung cancer cases hit 20,000 [Cancer Research UK] Despite falling smoking rates, the number of lung cancer cases are yet to fall in women. This reflects different patterns in smoking behaviour, with men’s smoking peaking in the 1940s while women’s peaked around the 1970s.
	6.2 Implants mammaires
Faulty breast implant victims forced to repay compensation [The Telegraph] Around 100 British women who suffered health problems after the faulty implants leaked industrial-grade silicon into their bodies had been awarded interim payment of £2,500 each, two years ago, pending a full assessment of their condition.
	6.8 Communication
Shut up and sip your coffee - says Slate [Slate] The credibility of the science – and of the journalism – is threatened by miscommunication of observational data.
	6.9 Controverses
Celgene’s $138,000 Doctor Payment Left Off Study Disclosures [Bloomberg] A cancer doctor failed to disclose in a scientific journal that he had received more than $138,000 in cash and goods from Celgene Corp., even though he was assessing the company’s drug Revlimid.