Onco Actu du 23 juillet 2015

	1. Biologie
Resistance to cancer drug found to occur naturally in the breast [The Institute of Cancer Research] Breast Cancer Now-funded researchers have discovered that genetic mutations which promote resistance to a particular type of cancer treatment can be present in breast cells before breast cancer has developed.
	3. Prévention
Simple cooking methods flush arsenic out of rice [Nature News & Comment] Preparing rice in a coffee machine can halve levels of the naturally occurring substance.
Can rice give you cancer? 'Not if you cook it in a coffee percolator' [The Telegraph] “In our research we rethought the method of rice cooking to optimise the removal of inorganic arsenic and we discovered that by using percolating technology, where cooking water is continually passed through rice in a constant flow, we could maximise removal of arsenic."
	3.1 Tabac
E-cigarettes may be as addictive as traditional ones [American Chemical Society] The researchers tested commercial samples of liquids made for the devices and found that, by and large, the nicotine was in the most addictive form. They also determined that the concentration of nicotine varied and often didn’t match the concentrations the labels claimed.
	3.4 Chimioprévention
Treating common bacterial infection could help prevent stomach cancer [Cancer Research UK] "The benefits appear small, with the analysis suggesting that you would need to treat 124 people infected with H. pylori to prevent one case of stomach cancer.”
Can Antibiotics Prevent Deaths From Stomach Cancer? [Forbes] “For many years people have known that there’s an association between H. pylori and gastric cancer.” Moayyedi said. “So it made sense to ask this question.” We did show that the intervention decreased gastric cancer, but not mortality."
	5.3 Traitements - FDA, EMA,...
Funds Join Campaign to Pressure Pharma to Disclose Trial Data [Wall Street Journal] The effort is likely to escalate a closely watched battle that has increasingly placed the pharmaceutical industry on the defensive as researchers and regulators call for increased disclosure.
	5.3.4 Traitements - AMM (FDA, EMA)
European Commission Approves Merck’s Anti-PD-1 Therapy, KEYTRUDA® (pembrolizumab), for Both First-line and Previously-treated Patients with Advanced Melanoma | Merck Newsroom Home [Merck] KEYTRUDA Demonstrated Superior Survival versus Ipilimumab in a Phase 3 Clinical Trial.
	5.4 Traitements - Economie
Drug Companies Pushed From Far and Wide to Explain High Prices [NY Times] Dr. Jerry Avorn, a professor at Harvard Medical School and critic of some drug company practices, said the industry “has brought this on itself by charging prices that are so astonishing, it makes citizens wonder, ‘Where did this figure come from?’ ”
Experts support call for lower cancer drug prices [Reuters] The experts include former presidents of the American Society of Clinical Oncology and the American Society of Hematology. Among the group's recommendations is the call for a new regulatory body that would help set prices once drugs win approval by the U.S. Food and Drug Administration.
	6. Lutte contre les cancers
MD Anderson named as one of two Genome Characterization Centers [MD Anderson Cancer Center] “The MD Anderson GCC will perform extensive genomic, transcriptomic, and proteomic analysis of patients’ samples collected through multiple programs at NCI,” said J.C. Zenklusen, Ph.D., director of NCI’s The Cancer Genome Atlas (TCGA) program.
	6.10 Politiques
Senator offers tantalizing prospect of regulatory relief for biomedical researchers [Science] "While nothing’s certain in Washington, my guess is that we have a really good chance, early next year, of passing a new law built upon 21st Century Cures, or precision medicine, or changing policies that speed up treatments and cures."
	6.11 Patients
I help terminally-ill parents leave stories behind for their children [The Guardian] When working in end-of-life care the level of intimacy with someone changes completely. Time becomes the most precious commodity and communication is honest. To be able to give someone the chance to convey their dreams is an honour, but it takes its toll.
	6.7.3 DMP
AMA docs fed up with EHR woes [Healthcare IT News] The physician voices in the room were overwhelmingly negative, with many docs citing decreased efficiency, less time with the patient and considerable ongoing expenses as a big part of the problem.