Onco Actu du 8 juin 2015

	2.6 Etiologie - Environnement
California air quality rules to tighten after cancer risk estimate triples [The Guardian] Factories and oil refineries in southern California face a new crackdown on their emissions of air toxins, after experts in the state reported that breathing in pollution carries almost three times the risk of causing cancer than was previously thought, especially for children and babies.
	5.2 Pharma
Janssen Initiates Rolling Submission of Biologic License Application (BLA) for daratumumab with U.S. FDA for the Treatment of Multiple Myeloma [Johnson & Johnson] The regulatory submission for daratumumab will be primarily supported by data from the Phase 2 MMY2002 (SIRIUS) monotherapy study announced in May 2015 at the 51st Annual Meeting of the American Society of Clinical Oncology (ASCO), along with additional data from four other studies, including the Phase 1/2 GEN501 monotherapy study.
	5.3 Traitements - FDA, EMA,...
The life and legacy of oncology PROMs [BMJ Blogs] The FDA is right to set standards high in terms of the “quality” of Patient Reported Outcomes Measures (PROMs); however by ignoring ongoing patient validation of legacy instruments and starting from scratch with tool development, are we at risk of throwing out the baby with the bathwater?
	5.4 Traitements - Economie
NICE backs Bayer's Xofigo but rejects Ferring's Firmagon [Pharma Times] There was mixed news for prostate cancer patients in England and Wales after NHS cost regulators endorsed Bayer’s Xofigo but turned down Ferring’s Firmagon.
NICE publishes draft guidance for two prostate cancer treatments [NICE] - NICE is recommending radium-223 dichloride (also called Xofigo) as a treatment for some people with prostate cancer which has stopped responding to hormone therapy (known as hormone relapsed) and has spread to the bone (bone metastases). - Meanwhile, NICE has issued draft guidance not recommending degarelix depot - also called Firmagon and manufactured by Ferring Pharmaceuticals - to treat advanced, hormone dependent prostate cancer.
The Observer view on big pharma and lifesaving drugs [The Guardian] The guidelines on pricing need urgent overhauling.
	5.5.1 ASCO (général)
Immunotherapy, Targeted Drugs, Brain Cancer Research Among Highlights at Cancer Meeting [Dana-Farber Cancer Institute] Eagerly awaited new data from trials of immunotherapy drugs, vaccines to treat brain tumors, and improved treatments for blood cancers sparked waves of optimism at the year’s biggest cancer meeting.
ASCO 2015 round-up: immunotherapy continues to come of age [Cancer Research UK] A number of studies picked up global media attention, so let’s have a look at what some of the more exciting stories were.
	6. Lutte contre les cancers
NHS not prepared for issues faced by cancer survivors, says study [The Guardian] Recovering patients continue to experience symptoms and side-effects, with Macmillan calling on government to fund long-term recovery packages.
	6.1 Observation
Men are 50 per cent more likely to get oesophageal cancer than 30 years ago [Cancer Research UK] The latest figures show the number of men diagnosed with oesophageal cancer has rapidly risen from around 2,700 cases three decades ago to 5,740 cases in 2012.
How Britons learned to fight off infection, but now die from heart disease and cancer [The Guardian] There is another issue hidden in statistics, however, as Paul Workman, head of the Institute of Cancer Research, makes clear. “Cancer deaths overall may be high but we should note that 50% of cancer patients today are still alive 10 years after their condition was first spotted. Forty years ago that figure was around 25%.”
	6.11 Patients
Around the world in an autogyro: cancer survivor attempts a global first [The Guardian] When Norman Surplus was diagnosed with advanced bowel cancer at 40, it was “a body blow”. The prognosis gave him only a 40% chance of living for 18 months. He still gets emotional when he describes the “mental challenge” he faced 12 years ago, knowing that the odds were that very soon he would be leaving his young family behind.
	6.4 Médico-éco
How Crowdfunding Helps Patients Deal with the High Cost of Cancer Care [NBC News] On Go Fund Me, the largest crowdfunding website, there are 30,000 campaigns to fund cancer costs.
	6.7 DMP, Big Data & applis
Nearly 1million patients could be having confidential data shared against their wishes [The Telegraph] Peers warned that the failures could lead to people missing out on cancer screening services that could save lives.