Onco Actu du 5 juin 2015

	1. Biologie
Penn Researchers Home in on What's Wearing Out T Cells [Penn Medicine] T cell exhaustion study has possible implications for cancer and antiviral therapies.
	3.1 Tabac
Don't ban e-cigarettes, sell them under tight regulation [The Conversation] Banning a less harmful product (e-cigarettes) while allowing the most harmful (tobacco cigarettes) to be freely sold is an incoherent form of risk regulation. It also disadvantages smokers who may have difficulty quitting but want to reduce the risks of smoking.
Making smoking history: the case for a smoker’s licence [The Conversation] I and many colleagues advocated for Australia’s pioneering plain tobacco packs and today I’m always asked, “So what’s next in tobacco control?” The best next step is a smoker’s licence, that would operate in some of the same ways that we limit access to prescribed drugs.
	4. Dépistage, diagnostic et pronostic
Antibody discovery could lead to more targeted cancer scans [Cancer Research UK] The new technique attaches a radioactive molecule to specialised proteins – called antibodies - that can recognise different types of cell. And experts said it could lead to a more precise way of visualising tumours inside cancer patients.
Single Test for All Virus Exposure Opens Doors for Researchers [NY Times] The test can detect past exposure to more than 1,000 strains of viruses from 206 species — pretty much the entire human “virome,” meaning all the viruses known to infect people.
	4.10 Dép., diag. & prono. - Poumon
MD Anderson and Exact Sciences announce partnership to develop screening and diagnostic tests for lung cancer [MD Anderson Cancer Center] Molecular diagnostics leader and cancer center’s Moon Shots Program launch initiative to identify lung cancer in early stages.
Exact Sciences, MD Anderson Developing Blood Tests For Lung Cancer [Xconomy] The lung cancer endeavor could prove more challenging because the market is much more competitive than colon cancer diagnostics.
	4.12 Biopsies liquides
New Electrochemical Assay for Diagnosing Cancer Causing Mutations from Blood Samples [MedGadget] The article, appearing in Nature Chemistry, details the fabrication of an electrochemical clamp assay targeted towards detecting mutations in the KRAS gene, which is known to cause lung, colorectal and ovarian cancer.
	4.9 Dép., diag. & prono. - Sein
Breast cancer screening 'cuts deaths by 40%' expert panel says [NHS Choices] The current report is the considered opinion of the IARC, based on their evaluation of the evidence available to date. However, this doesn’t mean that all other scientists will agree, as they may interpret the studies and weigh up the benefits and harms differently.
	5. Traitements
Making cancer treatment more accessible [MIT News] MIT collaborates on a smaller, lighter delivery system for proton-beam radiotherapy.
	5.3.4 Traitements - AMM (FDA, EMA)
The FDA's Sentinel Initiative [Health Policy Briefs-HealthAffairs] The Food and Drug Administration has launched a new system to assess the safety of prescription drugs after they are approved for sale.
	5.4 Traitements - Economie
The Cancer Immunotherapy Market Will Capture Major-Market Sales of Over $13 Billion In 2023 and Will be Dominated by Immune Checkpoint Inhibitors [PRNewswire] Among the nine oncology indications that we forecast immunotherapy sales, NSCLC will be the most commercially lucrative; the majority of immune checkpoint inhibitor sales will be realized in NSCLC owing to the large number of drug-treatable opportunities in this coveted indication.
	5.5.1.1 ASCO (général) - Industriels
Top-Performing Biotech and Drug Stocks During ASCO '15 [TheStreet] I chose this 16-day trading period to track stock performance because it begins with the public release of ASCO research abstracts on May 13 and ends the day after the meeting concluded.
	5.5.12 ASCO (médico-éco)
And then there were five [The Economist] The new treatments look promising. But they do not look cheap.
	5.5.13 ASCO (divers)
Study suggests link between cholesterol drugs and lower risk of cancer death [Cancer Research UK] The findings, reported at the American Society of Clinical Oncology (ASCO) annual conference in Chicago, showed lower death rates among those taking statins for several common cancers including breast, bowel and ovarian cancers. But lung cancer death rates did not seem to be affected, contrary to previous research.
	6. Lutte contre les cancers
Houston Methodist Hospital, MD Anderson Cancer Center teams perform first multi-organ transplant that includes skull and scalp [MD Anderson Cancer Center] James Boysen, a 55-year-old software developer from Austin, Texas, is the first patient to receive the simultaneous craniofacial tissue transplant together with solid organ transplants.
World's First Skull-Cap Transplant Helps Jim Boysen Fight Cancer [Hufffington Post] Opening a new frontier in transplant surgery, Texas doctors have done the world's first partial skull and scalp transplant to help a man who suffered a large head wound from cancer treatment.
	6.10 Politiques
European Commission Rejects Petition to Abolish Animal Research [Wall Street Journal] Animal rights activists suffered a setback as the European Commission yesterday rejected a petition that, effectively, called for a ban the use of animals in research for drug development. Specifically, the commission decided not to repeal a directive that seeks to phase out animal testing.
	6.11 Patients
Well: Living With Cancer: Keep On Cooking [NY Times] We represent a new phenomenon of patients living longer with cancer: Two out of three people diagnosed with invasive cancer now survive for five years or more. When strong enough, we slice, simmer and serve what we can savor on the mutable menu of possibilities.
	6.7 DMP, Big Data & applis
Amazon, Google race to get your DNA into the cloud [Reuters] Now an estimated $100 million to $300 million business globally, the cloud genomics market is expected to grow to $1 billion by 2018, said research analyst Daniel Ives of investment bank FBR Capital.