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1. Biologie
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Angeliki
and her team have been studying a molecule called Kinesin-5 (also known
as Eg-5), which is essential for centrosomes to function properly.
Without it, the centrosomes don’t separate after they’ve been copied,
remaining in the centre of the cell rather than moving to each end.
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2.6 Etiologie - Environnement
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The
taskforce of 174 scientists in 28 countries investigated 85 prototypic
chemicals that were not considered to be carcinogenic to humans, and
they reviewed their effects against a long list of mechanisms that are
important for cancer development.
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IARC
said it decided on the “possibly” classification because there was
“inadequate evidence in humans and limited evidence in experimental
animals” of ties between 2,4-D and cancer.
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The
IARC said it reviewed the latest scientific literature and decided to
classify 2,4-D as "possibly carcinogenic to humans." That is a step
below the more definitive "probably carcinogenic" category but two steps
above the "probably not carcinogenic" category.
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4.10 Dép., diag. & prono. - FDA, EMA, NICE,...
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“Traditionally,
GPs have always had some tests available such as blood tests, X-rays
and some scans. This guidance expands this by bringing some tests that
have been traditionally thought to be hospital tests under the wing of
GPs. It will open the door for smarter testing so that people with
cancer will receive their diagnosis much earlier. There is no doubt in
my mind that this guideline will help to save lives.”
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It’s
now up to us as GPs, along with those in specialist services and the
government, to put these new guidelines into practice. They’re hundreds
of pages of long, and it will take a concerted effort to train everyone
involved and make the necessary changes to services.
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Charities say they support the changes but warn that more funds are needed.
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Thousand
of lives will be saved every year if GPs and patients act on new NHS
guidance, which details for the first time the symptoms that could
indicate cancer.
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The
new advice from the National Institute for Health and Care Excellence
(Nice) comes amid concern that Britain has one of the lowest cancer
survival rates in Western Europe.
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4.12 Biopsies liquides
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Plans
to Release Up to Six New Lab-Based Cancer Tests This Year Targeting
Actionable Mutations in Melanoma, Lung Cancer and Colorectal Cancer for
Use with Tissue or Liquid Biopsy Samples.
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4.9 Dép., diag. & prono. - Sein
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This
latest research, led by teams at The Institute of Cancer Research,
London and The Royal Marsden, has shown that levels of ER expression –
just one of the genetic markers that the Oncotype DX test picks up – had
a substantial effect on risk of the disease recurring and may be useful
in determining who may or may not benefit from extended therapy.
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This
unnecessary imaging adds up to many millions of dollars in extra costs,
does not help the patient, and can harm her, Clemons said. “Clearly in
this setting, more is certainly not always better,” he said.
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5.2 Pharma
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Tazemetostat
is a small molecule drug designed to switch off the activity of a
specific enzyme—a type of histone methyltransferase called EZH2—that’s
implicated in a variety of cancers.
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Looking
to step ahead of CAR-T pioneers like Juno and Novartis, which are
reengineering T cells by adding chimeric antigen receptors (CARs) that
make them into personalized cancer-cell-killing vehicles, Soon-Shiong's
Conkwest is adapting an engineered lineup of natural killer cells, or NK
cells, that he believes will be much more efficient cell assassins.
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5.2.1 Pharma - Partenariats
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Under
the deal, Kite will bring its expertise in T cell receptor, or TCR,
treatments, which rely on rewiring the body's immune cells to home in on
cancers. And bluebird will provide its know-how in using harmless
viruses to deliver corrective genes and its experience in gene editing.
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5.4 Traitements - Economie
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Helmed
by Peter Bach, who directs the hospital's Center for Health Policy and
Outcomes, the interactive calculator--dubbed DrugAbacus--tweaks prices
using data on side effects, survival benefits, disease incidence,
R&D spending and more.
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Framework to support shared decision-making between doctors and patients; ASCO solicits public comment.
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The
panel -- set to the task by the American Society of Clinical Oncology
-- hopes to make its proposed "Value Framework" a comprehensive and
widely available resource for patients with the full range of cancers.
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The
release by the American Society of Clinical Oncology of what it calls
its “value framework,” is part of a change in thinking among doctors,
who once largely chose drugs based on their medical attributes alone.
The major cardiology societies, for instance, are also now starting to
factor cost into their evaluation of drugs.
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6. Lutte contre les cancers
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The
fear is that massage can push cancer cells round the body: it’s a
nonsense, and in fact my radiotherapy for breast cancer came with a
course of massages from a specially-trained Macmillan therapy team.
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6.10 Politiques
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President
Obama also announced his intent to appoint the following individuals to
the National Cancer Advisory Board: Peter C. Adamson, Deborah Watkins
Bruner, Yuan Chang, Timothy J. Ley, Max S. Wicha.
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6.11 Patients
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At
a hastily convened news conference here, Mr. Hogan, 59, said that he
had an aggressive form of B-cell non-Hodgkin’s lymphoma that had spread
quickly, with tumors in his neck, chest, groin and abdomen, but that his
doctors had assured him that he had a “strong chance of survival” and
recovery.
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I
am the only family member who has ever read Zach’s autopsy report. It
was beyond painful to read but eye-opening in its revelation of the way
current treatment regimens left a damaging mark on every organ system. I
knew there had to be a better way, and this thought consumes me daily.
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6.7 DMP, Big Data & applis
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To
achieve this, the authors recommend the EHR manufacturers not only
retool, but adopt a uniform and open source approach to API development.
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6.7.2 Applis
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Available
now on the App Store, Epic’s MyChart app for Apple Watch allows
patients to view alerts for new test results, billing statements and
health maintenance reminders are accessible on their iPhone. Patients
who use the app must create an account with Nebraska Medicine.
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6.8 Communication
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A
new blog by Andrew Howard, MD, radiation oncologist at the University
of Chicago and the University of Illinois at Chicago, fits right in with
this innovative bunch. His blog, Cancer Ninja, aims to use cartoons to
convey both how cancer works and what it’s like to be diagnosed and
treated for it.
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