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1. Biologie
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Regev
says she has been working with the new methods to classify cells in
mouse retinas and human brain tumors, and she is finding cell types
never seen before. “We don’t really know what we’re made of,” she says.
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3.1 Tabac
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Chris
Woodhall, Cancer Research UK’s senior tobacco control officer, welcomed
the findings, but cautioned that they would need to be replicated among
UK smokers.
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We are encouraged by the recognition by many members of Congress that we must protect youth from these products.
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More
people signed up to program that offered $800 cash than one that
threatened them with losing a $150 deposit – but fewer gave up.
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These
results have exciting implications for how to help smokers quit. First,
as behavioral scientists would have predicted, the risk of losing money
is better for inspiring cessation behavior than the potential to make
money.
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The
Penn researchers concluded that simply paying smokers to quit was the
most “effective” way to go because people were so much more willing to
give it a try.
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3.3 Prévention - Vaccins
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The
only real barrier to full implementation is ideology – distrust of
science, medicine, government, or corporations, irrational worship of
the concept of “natural”, belief in magical medical nonsense, or the
misguided belief that preventive measures promotes immoral behavior.
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4.1 Dép., diag. & prono. - Prostate
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Data
Presented at American Urological Association Annual Meeting Underscore
Test's Value to Physicians, Patients and U.S. Healthcare System.
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In
the validation data featured at AUA, the pre-defined AS threshold was
evaluated in 765 conservatively managed men, and the clinical endpoint
was 10-year risk of prostate cancer mortality.
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4.10 Dép., diag. & prono. - Poumon
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The
company's Percepta Bronchial Genomic Classifier takes cell samples from
the windpipe of smokers during a bronchoscopy procedure and analyzes 23
genes for their reaction to exposure to cigarette toxins.
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4.2 Dép., diag. & prono. - Génome
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It
is a rare but delightful opportunity to learn about something from an
acknowledged world expert. Such was the case last month when I heard
Mary-Claire King give the Stanley J. Korsmeyer Memorial lecture,
hands-down one of the best talks I’ve ever heard. She was a wonderful
public speaker: funny, charming, and straight-shooting.
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The
workshop examined how a variety of systems are capturing and making use
of genomic data to generate knowledge for advancing health care in the
21st century. It also sought to evaluate the challenges, opportunities,
and best practices for capturing or using genomic information in
knowledge-generating health care systems.
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"All
of a sudden, it all opened up," as companies recognize the potential
for drugs targeting genetic glitches, Dr. Eric Topol, a genomics expert
at the Scripps Translational Science Institute. "It's starting to really
become a new preferred model for drug development."
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4.9 Dép., diag. & prono. - Sein
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As
a nation, we’ve invested billions in research to improve our ability to
prevent, screen for, diagnose and treat breast cancer. Let’s use it to
better inform patients and their doctors and protect patients from
unnecessary harm.
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5. Traitements
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TAS-102,
a combination of trifluridine and tipiracil in which tipiracil
interferes with the deactivation of trifluridine, improved overall and
progression-free survival in patients whose disease had progressed after
treatment with fluorouracil-containing drug combinations.
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They
found that by using drugs to block a molecule called WEE1 – which keeps
cell division under control until DNA has been properly checked for
errors – they could force cancer cells to make so many mistakes in
their genetic code that they could no longer survive.
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A
drug developed 50 years ago and abandoned because it was considered to
be too toxic has gained a second life in an international clinical
trial.
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The
study, using mouse models, data from The Cancer Genome Atlas (TCGA) and
human tumor samples, found that FGL2 increased tumor growth in mice by
enhancing immune checkpoint gene expression. The research team
neutralized the protein by using an anti-FGL2 antibody.
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5.12 Immunothérapies
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Entitled
“Translating Science into Survival,” the meeting will feature more than
60 talks by acknowledged leaders in the field covering all areas of
inquiry in cancer immunology and immunotherapy.
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This
is a story about the velocity of an idea – a discovery whose potential
to improve cancer treatment practically leapt from the test tube.
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5.2 Pharma
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The
failure follows a similar setback for orteronel, a once-promising
prostate cancer treatment that Takeda ditched last year after it came up
short in Phase III. The company's most advanced cancer treatment is now
ixazomib, an oral treatment for blood cancers that Takeda hopes can
succeed its blockbuster Velcade.
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5.2.1 Pharma - Partenariats
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“Data
analysis suggests that Cynviloq meets the bioequivalence (BE) criteria
for both total and unbound paclitaxel,” Sorrento said on May 4.
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Cynviloq
is in the midst of a Phase III study in breast and lung cancers with
the goal of demonstrating bioequivalence to Abraxane, which uses the
protein albumin to deliver a targeted blast of paclitaxel and kill
tumors.
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5.4 Traitements - Economie
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Non-tyrosine
kinase inhibitors have gradually gained attention in the last few
years. Amongst the marketed drugs, Nexavar and Afinitor have already
achieved blockbuster status.
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6. Lutte contre les cancers
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As
a patient working in cancer research for over ten years now, one thing
has slowly become more and more apparent. The greatest patient benefit
accrues from studies which are academically led. A bold statement which
needs a bit of unpicking.
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6.10 Politiques
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For
the last four years, I have served on the Advisory Council of the
National Center for Advancing Translational Sciences (NCATS), which is
part of the National Institutes of Health (NIH). A disheartening
discovery from that experience has been the bias for funding safe
science – at the expense of bold science – that pervades publicly-funded
research.
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The final bill should come up for a vote on the floor of the full House of Representatives sometime in June.
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The
language in the Discussion Draft may continue to change as the bill
works its way through the legislative process. Still, the proposal to
date reflects a step in the right direction.
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Throughout
the last parliament, the Conservatives championed the benefits of
medical research and the life sciences and their potential to boost
economic recovery. But there are big spending cuts that have to be made
and, apart from three protected areas, the NHS, schools and
international aid, all departments are vulnerable.
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6.11 Patients
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Four
men have turned to photography, in a pilot project funded by Prostate
Cancer UK, to share their views and experience of living with the
disease
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I
don’t want cancer to change my life. But the night after my first
chemotherapy session, I swore to my fiance I wouldn’t go through it
again.
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Since
I was diagnosed with breast cancer last summer, I’ve had surgery,
chemotherapy and radiotherapy, and my appearance has undergone a major
overhaul. Now, most of you avoid my eye, don’t smile and rarely stop for
a chat. None of you is oblivious (even though you appear to be),
because my cancer diagnosis is known throughout the school.
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6.8 Communication
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When
it comes to sending a message to the country and the world about who
should be screened and when they should start screening, we should use
the opportunity to educate and inform about what we know, not what we
assume.
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6.9 Controverses
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They
say overdiagnosis and overtreatment are driven by "a culture of 'more
is better', where the onus on doctors is to 'do something' at each
consultation".
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