Onco Actu du 8 avril 2015

Sommaire 4. Dépistage, diagnostic et pronostic Policy Issues in the Development and Adoption of Biomarkers for Molecularly Targeted Cancer Therapies: Workshop Summary [The National Academies Press] 4.9 Dép., diag. & prono. - Sein Automated Ultrasound Can Improve Breast Cancer Detection In Women With Dense Breasts [Forbes] 5. Traitements RNA as an Anticancer Drug Target [GEN] More toxic, better targeted: are we one step close to that magic bullet? [Cancer World] 5.2 Pharma Clovis one-ups AstraZeneca with a 'breakthrough' tag for its cancer drug [FierceBiotech] 5.3 Traitements - FDA, EMA,... EU approves Roche's Avastin plus chemotherapy for women with advanced cervical cancer [Roche] 5.4 Traitements - Economie No real rationale for rising cancer drug prices, JAMA researchers conclude [FiercePharma] Cancer Immunotherapy Is All Over The Science News -- And Now It Has Its Own Stock Index [Forbes] 6. Lutte contre les cancers The future of the postdoc [Nature News & Comment] 6.1 Observation Childhood cancer survival increases by 6%, despite small rise in cases in young [The Guardian] UCLA researchers find that income inequality affects who gets an underutilized breast cancer test [National Cancer Institute] Alarm over sudden drop in female life expectancy [The Telegraph] 6.6 Publications IF: Impact Factor....or inflation factor? [The Mermaid's Tale] 7 Tips to Quickly Crafting Your Next Research Article [Bitesize Bio]

Les étoiles de couleur jaune signalent des articles dont la lecture est en priorité suggérée (1*) ou recommandée (3*). 4. Dépistage, diagnostic et pronostic Policy Issues in the Development and Adoption of Biomarkers for Molecularly Targeted Cancer Therapies: Workshop Summary [The National Academies Press] This report highlights the presentations and discussions at the workshop convened in November 2014 by the Institute of Medicine's National Cancer Policy Forum to discuss recent trends in the development and implementation of molecularly targeted cancer therapies and explore potential policy actions to address specific challenges. 4.9 Dép., diag. & prono. - Sein Automated Ultrasound Can Improve Breast Cancer Detection In Women With Dense Breasts [Forbes] Some radiologists have little or no training in the sound-wave method of scanning whole breasts for cancer. If they dabble in ultrasound, they wind up with an unacceptably high rates of false positives. If they lack practice – or confidence – in distinguishing malignant from benign tissue, they’ll perform too many biopsies in women who don’t have cancer. 5. Traitements RNA as an Anticancer Drug Target [GEN] "We've discovered a new way that human cells control cancer gene expression, at the step where the genes are translated into proteins. This research puts on the radar that you could potentially target mRNA where these tags bind with eIF3." More toxic, better targeted: are we one step close to that magic bullet? [Cancer World] Could the new generation of antibody–drug conjugates herald a move away from conventional untargeted chemotherapy? Much will depend on how far – and in whom – their added benefit can justify the high cost of these technologically sophisticated drugs. 5.2 Pharma Clovis one-ups AstraZeneca with a 'breakthrough' tag for its cancer drug [FierceBiotech] The drug, rucaparib, works by inhibiting enzymes called poly ADP ribose polymerases, or PARPs, getting in the way of the process that allows certain gene mutations to spread cancer throughout the body. 5.3 Traitements - FDA, EMA,... EU approves Roche's Avastin plus chemotherapy for women with advanced cervical cancer [Roche] The EU approval was based on the significant survival benefit in the pivotal GOG-0240 study, which showed that women who received Avastin plus chemotherapy had a statistically significant 26 percent reduction in the risk of death, representing a median improvement in survival of nearly four months, compared to women who received chemotherapy alone. 5.4 Traitements - Economie No real rationale for rising cancer drug prices, JAMA researchers conclude [FiercePharma] Cancer drug prices are rising faster than the prices of treatments for other diseases, and that's worrisome to patients, doctors and policy researchers, the study authors wrote. And unfortunately, the argument for those rising costs isn't very reasonable, they said. Cancer Immunotherapy Is All Over The Science News -- And Now It Has Its Own Stock Index [Forbes] It contains 25 companies worth at least $100 million or more, including big, diversified companies like Bristol-Myers Squibb and Merck, as well as smaller companies focused entirely on immunotherapy, like Juno Therapeutics and Kite Pharma. 6. Lutte contre les cancers The future of the postdoc [Nature News & Comment] There is a growing number of postdocs and few places in academia for them to go. But change could be on the way. 6.1 Observation Childhood cancer survival increases by 6%, despite small rise in cases in young [The Guardian] Childhood cancer survival has increased in Australia by 6% over recent decades, despite a small unexplained rise in incidence rates among the very young. Overall childhood cancer mortality rates decreased by about 4% a year between 1998 and 2010. UCLA researchers find that income inequality affects who gets an underutilized breast cancer test [National Cancer Institute] Wealthier women who live in communities with the greatest income divide between rich and poor had better access to a new genetic test that can determine the most effective form of treatment for early-stage breast cancer, according to a new study. Alarm over sudden drop in female life expectancy [The Telegraph] Experts said the trend could be the result of changes in the lifestyles of the “baby boomer” generation, with older women more likely to drink regularly, and to have smoked, than previous generations. 6.6 Publications IF: Impact Factor....or inflation factor? [The Mermaid's Tale] An obvious question one should be why anybody would tally impact factors in the first place? Who has what to gain? 7 Tips to Quickly Crafting Your Next Research Article [Bitesize Bio] Here are the few tips for you to craft the next manuscript easily and quickly. It may not be the perfect one, but will allow you to produce the first draft, which can then be honed and nurtured further to produce the perfect one for final submission.