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Les étoiles de couleur jaune signalent des articles dont la lecture est en priorité suggérée (1*) ou recommandée (3*). |
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3.1 Tabac
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A ban on the
sale of electronic cigarettes to under-18s has been announced in England
and similar measures are being considered in England, Wales, Scotland
and Northern Ireland.
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But while the
devices might help smokers quit their habit, some researchers are
concerned that people will become addicted to the nicotine in
e-cigarettes instead. The long term health consequences are vaping are
not yet well known.
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A survey of 14
to 17-year-olds in the north west of England found that one in five had
acquired e-cigarettes even though the government is bringing forward
laws to ban their sale to under 18s.
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4. Dépistage, diagnostic et pronostic
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As cells
become cancerous, some proteins on their outer membranes shed sugar
molecules and become less slimy, perhaps because they're crowded closer
together. If we tune the MRI to detect sugars attached to a particular
protein, we can see the difference between normal and cancerous cells.
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4.5 Dép., diag. & prono. - Colorectal
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Multi-Disciplinary Guidance Document Focuses on Using Molecular Markers to Optimize Patient Care.
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5. Traitements
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In a study
published in Cancer Cell, the researchers tested two compounds they
developed, MI-463 and MI-503, in cell lines and in mice with MLL
leukemia.
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When are the
costs of surgery too great? It’s long been a burning question in
prostate cancer, and papers presented over the past few days at the
European Association of Urology’s conference in Madrid have added a few
more pieces to the risk versus benefits jigsaw.
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Generics
markets are gearing up for the expiry of patents on some of the first
targeted cancer drugs. It's good news for greater access, but patients
want reassurance that switching to generics wont put them at risk.
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5.2 Pharma
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Novartis says
it is ‘stepping up its efforts’ in cancer by launching major initiatives
to discover new treatments to combat the disease.
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5.2.1 Pharma - Partenariats
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Four months
after Pfizer stepped up with a $2.85 billion promise to partner with
Merck KGaA on a preclinical PD-L1 oncology effort, the German pharma
company has turned around to partner with Intrexon on an upstart CAR-T
cancer drug development project.
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Current
approaches with checkpoint inhibitors and T-cell modulation are potent
but only in select tumor types. STING agonists have the potential to
fully activate the immune system to attack a broader range of tumors.
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The program
aims to develop new immunotherapy treatments for cancer based on
preclinical work by the Southampton group showing the potential to treat
cancer using antibodies targeting OX40 and 4-1BB – known ‘co-receptors’
that help stimulate the production of killer T-cells during an immune
response.
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The move gives
Novartis access to Aduro's experimental STING (Stimulator of Interferon
Genes) technology, which is a next-generation method to harness the
body's immune system to combat cancer.
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5.3 Traitements - FDA, EMA,...
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Dinutuximab is
a monoclonal antibody that binds to a molecule known as GD2. This
molecule, a ganglioside (a complex molecule that contains both lipids
and carbohydrates), is expressed on the surface of neuroblastoma cells.
Binding of dinutuximab to GD2 initiates an immune response that can kill
the cells.
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FDA's newly
finalized guidance document, Critical Path Innovation Meetings, explains
how stakeholders can set up meetings with FDA to discuss a methodology
or technology which might enhance drug development.
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6. Lutte contre les cancers
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Working Group to host public meetings, seek public input into the design of the Initiative.
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In a letter to
colleagues announcing his departure as the director of the National
Cancer Institute, Dr. Harold Varmus, 75, quoted Mae West. “I’ve been
rich and I’ve been poor,” he wrote, “and rich is better.”
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6.1 Observation
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This report is
one of several regularly released reports that provide information on
important cancer trends in the United States.
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The new report
suggests that some of the differences in rates of breast cancer
incidence and mortality across racial and ethnic groups are related to
differences in the incidence of different subtypes.
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The analysis,
published in the Journal of the National Cancer Institute, is the latest
in a series of annual reports on cancer compiled since 1998 by the
NAACCR, the ACS, the Centers for Disease Control and Prevention and the
National Cancer Institute.
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6.10 Politiques
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The
right-to-die movement has gained renewed momentum in California and
around the nation following the highly publicized death of Brittany
Maynard. The 29-year-old with brain cancer moved from California to
Oregon to take advantage of its "Death with Dignity" law and died in
November after taking a fatal dose of barbiturates prescribed by her
doctor.
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6.11 Patients
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“Doc, can I go
on a cruise?” For someone who has never been on one, I have learnt a
lot about cruises through being an oncologist.
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6.4 Médico-éco
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When it
launches next month, Choosing Wisely Australia® will start an important
national conversation about reducing the many low value and often
potentially harmful tests, treatments and procedures that have become
entrenched in healthcare.
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6.8 Communication
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Cancer will
always be in our midst for one simple scientific reason: the very genes
that allow us to grow and adapt, when mutated, lead to cancer. And these
are not incidental genes – we are not talking about the periphery of
human physiology – we are talking about the genes that function as the
centerpieces of normal cellular growth and development.
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The coming
days will illustrate what I am referring to: how we communicate about
the exciting work that is presently going on at NCI and in the cancer
research community, but also about the future of cancer research and
treatment.
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Unusual for a
TV story, the anecdotes presented balanced positive findings with one
cautionary tale in the form of a woman who underwent the procedure,
became partially paralyzed, dropped out of the trial and died.
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More than 40
members of the AACR, including the AACR’s President-elect José Baselga,
MD, PhD, and immediate Past President Charles Sawyers, MD, are featured
in the documentary, along with 17 fellows of the AACR Academy.
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“I was very
impressed by how the filmmakers saw cancer as a problem in evolution –
that’s not a new notion, but it’s important if you really want to
understand the problem we’re facing now.”
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