Onco-Actu du 26 mars 2015

Sommaire 2.5 Etiologie - Gènes Amgen Releases A Giant Genetic Portrait Of A Nation -- And A Map Of The Future [Forbes] Genome Study Predicts DNA of the Whole of Iceland [Reuters] In Iceland’s DNA, New Clues to Disease-Causing Genes [NY Times] 4.1 Dép., diag. & prono. - Prostate Using multiple imaging measures could improve prostate cancer diagnosis [Institute of Cancer Research] 4.9 Dép., diag. & prono. - Sein NHS 'failing to protect' older women from breast cancer [The Telegraph] 5. Traitements Why Doctors Are Trying A Skin Cancer Drug To Treat A Brain Tumor [NPR] High hopes for hypofractionation in search for cheaper, better radiotherapy [Institute of Cancer Research] 5.2 Traitements - Pharma Cellectis pulls off a $228M IPO to bankroll its CAR-T ambitions [FierceBiotech] VBL Therapeutics' brain cancer drug succeeds in mid-stage study [Reuters] 5.4 Traitements - Economie NICE issues final guidance on pomalidomide (Imnovid) for blood cancer [NICE] 6. Lutte contre les cancers Well: How Exercise May Aid Cancer Treatment [NY Times] 6.1 Lutte - Observation Is cancer care at a crossroads? [BBC News] New global cancer map aims to improve care in developing countries [Scope Blog] 6.11 Lutte - Patients A Woman's Journey From Cancer Diagnosis To 'Professional Patient' [NPR] 6.5 Lutte - Médecines alternatives Medical marijuana and the new herbalism, part 3: Cannabis does not cure breast cancer [Respectful Insolence] 6.8 Lutte - Communication Why Might A Woman Have Her Ovaries Removed? [Memorial Sloan Kettering Cancer Center] Jolie can start a health conversation, but she mustn’t be the last word [The Globe and Mail]

2.5 Etiologie - Gènes Amgen Releases A Giant Genetic Portrait Of A Nation -- And A Map Of The Future [Forbes] 26/03/2015 - www.forbes.com “I am an old-fashioned physician, and if I know of people who are at an 86% risk of cancer I just want to go with them and prevent this from happening,” Stefansson says. “But there are those who want to approach them indirectly. That is the debate for society.” Genome Study Predicts DNA of the Whole of Iceland [Reuters] 25/03/2015 - www.technologyreview.com The CEO of an Icelandic gene-hunting company says he is able to identify everyone from that country who has a deadly cancer risk, but has been unable to warn people of the danger because of ethics rules governing DNA research. In Iceland’s DNA, New Clues to Disease-Causing Genes [NY Times] 25/03/2015 - www.nytimes.com “From the technical point of view, these papers are a tour-de-force,” said David Reich, a geneticist at Harvard Medical School who was not involved in the research. 4.1 Dép., diag. & prono. - Prostate Using multiple imaging measures could improve prostate cancer diagnosis [Institute of Cancer Research] 26/03/2015 - www.icr.ac.uk Researchers found they achieved optimal detection of tumours by analysing a series of parameters taken by magnetic resonance imaging, including measures of blood vessel growth and of choline, polyamines and creatine. 4.9 Dép., diag. & prono. - Sein NHS 'failing to protect' older women from breast cancer [The Telegraph] 26/03/2015 - www.telegraph.co.uk Calls for older women to be screened for breast cancer have been ignored by the NHS, with funds unfairly diverted to younger women, MPs have warned. 5. Traitements Why Doctors Are Trying A Skin Cancer Drug To Treat A Brain Tumor [NPR] 26/03/2015 - www.npr.org Her oncologist, David Hyman at Memorial Sloan Kettering, enrolled Anselmo into a new kind of drug trial. Called a basket trial, the study is designed to include people whose tumors have the same kind of genetic fingerprint regardless of where in the body the tumors are found. High hopes for hypofractionation in search for cheaper, better radiotherapy [Institute of Cancer Research] 26/03/2015 - www.icr.ac.uk Giving radiotherapy in fewer treatments but at higher doses could work just as well as standard regimes, but be cheaper and more convenient for patients. 5.2 Traitements - Pharma Cellectis pulls off a $228M IPO to bankroll its CAR-T ambitions [FierceBiotech] 26/03/2015 - www.fiercebiotech.com Unlike industry leaders Novartis, Juno Therapeutics and Kite Pharma, Cellectis' approach to CAR-T uses off-the-shelf T cells harvested from third-party patients, a method the company believes will lead to best-in-class therapeutics. VBL Therapeutics' brain cancer drug succeeds in mid-stage study [Reuters] 25/03/2015 - www.reuters.com The company said it expected to begin the only required late-stage study of VBL-111 by mid-2015, according to an agreement with the U.S. Food and Drug Administration. 5.4 Traitements - Economie NICE issues final guidance on pomalidomide (Imnovid) for blood cancer [NICE] 26/03/2015 - www.nice.org.uk NICE has issued final guidance to the NHS not recommending pomalidomide for treating multiple myeloma. 6. Lutte contre les cancers Well: How Exercise May Aid Cancer Treatment [NY Times] 25/03/2015 - well.blogs.nytimes.com In a new study involving mice, aerobic exercise slowed the growth of breast cancer tumors and made the cancer more sensitive to chemotherapy. The results raise the possibility that exercise may change the biology of some malignant tumors, potentially making them easier to treat. 6.1 Lutte - Observation Is cancer care at a crossroads? [BBC News] 26/03/2015 - www.bbc.com The study found Britons were much more likely to be embarrassed about coming forward or put off by fear they may be wasting the time of their doctor than people from other countries. When it comes to cancer, the problems may be more intractable than the headlines suggest. New global cancer map aims to improve care in developing countries [Scope Blog] 26/03/2015 - scopeblog.stanford.edu The nonprofit Global Oncology, Inc. has launched a Global Cancer Project Map, a first-of-its-kind resource that will connect cancer experts around the world in an effort to advance cancer research and care in low-resource areas. 6.11 Lutte - Patients A Woman's Journey From Cancer Diagnosis To 'Professional Patient' [NPR] 26/03/2015 - www.npr.org When would Josephson decline treatment? "It would be at the point where it was pretty hopeless," she says. "But I haven't gotten to that point yet at all, not in my mind and not in reality. And I've discussed it with the kids, and I said, 'Don't you dare pull the plug on me too fast.' " 6.5 Lutte - Médecines alternatives Medical marijuana and the new herbalism, part 3: Cannabis does not cure breast cancer [Respectful Insolence] 26/03/2015 - scienceblogs.com As much as I admire the grace and determination with which Stefanie LaRue has endured over 9 years after her cancer diagnosis, as a cancer doctor it bothers me profoundly that she has allowed herself to fall under the spell of the “cannabis cures cancer” alternative medicine crowd. 6.8 Lutte - Communication Why Might A Woman Have Her Ovaries Removed? [Memorial Sloan Kettering Cancer Center] 26/03/2015 - www.mskcc.org Up until now, we have only been able to tell a woman who tests positive for a BRCA mutation that her risk for developing cancer ranges from 40 to 90 percent. Jolie can start a health conversation, but she mustn’t be the last word [The Globe and Mail] 25/03/2015 - www.theglobeandmail.com My own work on this issue demonstrated that the news media had an overwhelmingly positive slant toward Ms. Jolie’s decision to get a double mastectomy. But the stories almost always overlooked the relative rarity of her situation. Important context was left out.