vendredi 28 octobre 2016

Onco Actu du 28 octobre 2016

1. Biologie

Mutations in bone cells can drive leukemia in neighboring stem cells [Emory]

Zebrafish reveal brain tumour’s secret ally [Cancer Research UK]

3.1 Tabac

This machine smokes up to 10 cigarettes at a time — in the name of science [STAT]

4. Dépistage, diagnostic et pronostic

Searching the Human Immune System for Clues to Cancer [MIT Technology Review]

Promising Blood Test Fails to Yield Clues About Best Strategies for Bladder Cancer Treatment [Penn Medicine]

4.13 Dép., diag. & prono. - Peau

The Myriad myPath® Melanoma Test Effectively Diagnosed Patients in the Largest Outcomes-Based Study for a Melanoma Diagnostic [Myriad]

4.5 Dép., diag. & prono. - Colorectal

Exact Sciences Shares Dip After Company Adjusts Revenue Forecast [Xconomy]

5. Traitements

Drug targeting tumor metabolism discovered by MD Anderson’s Institute for Applied Cancer Science enters clinical trial [MD Anderson]

More Than Was Asked For [In the Pipeline]

‘Unexpected’ Vulnerability Creates Treatment Opportunity in Aggressive Type of Lung Cancer [NCI]

5.12 Immunothérapies

Big Improvement for Immunotherapy Could Come from Small Molecule [GEN]

Bruised by a punishing Opdivo failure, Bristol-Myers looks to shake up the business, accelerate R&D [EndPoints]

5.12.2 Immunothérapies - CAR-T

New approach to cancer treatment carries success with caveat [Harvard]

5.12.4 Immunothérapies - Essais

FDA slaps a partial hold on one of AstraZeneca’s crucial durvalumab programs [EndPoints]

AstraZeneca pauses two cancer drug trials' enrolment due to bleeding [Reuters]

5.2.2 Pharma - Fusions & Acquisitions

ASCO star, backed by billionaires, goes to Astellas in $1.4 billion buyout [EndPoints]

Astellas to Acquire Ganymed Pharmaceuticals -Acquisition Would Expand Astellas' Oncology Pipeline with Antibody in Late-Stage [Astellas]

5.4 Traitements - Economie

High stakes in ballot battle over rising prescription drug costs [HealthNewsReview]

5.6 ESMO

ESMO Symposium on Immuno-Oncology 2016 [ESMO]

6.11 Patients

Patient values may not always align with choices for end of life care [Reuters]

6.7 DMP, Big Data & applis

Stopping Breast Cancer with Help from AI [MIT Technology Review]

6.9 Controverses

'Patient choice' is NHS lingo for buck-passing and blame-dodging. Doctors, not us, know best [The Telegraph]